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Evolution of Cardiovascular system
multicellularity and tissue specialization, coupled with increased size, require bulk transport of important materials
Components of bulk transport systems
propulsive organs (hearts; chambered, tubular, ampullar, pulsating vessels) pressure réservoir and distributors (arteries) transfer systems (capillaries)
two types of bulk transport systems
open and closed
how to calculate bulk flow
M = k[P1 - P2]
describe open circulatory system
hemolymph vessels 30% blood volume 5-10 mm Hg no capillaries one pump
describe closed circulatory system
blood vessels 5-10% blood volume 75-150 mm Hg multicellular animals
Systolic Pressure
Blood pressure in the arteries during contraction of the ventricles
diastolic pressure
blood pressure that remains between heart contractions
Bernoulli's Equation
describes the energy relationships in nonviscous fluid under constant flow E=P + 1/2pv2 +mgh
Poiseuille's Equation
describes fluid flow through a rigid vessel
Vertebrate skeletal muscle
-In the vertebrate plan twitch muscles are innervated by 100-1k motor neurons -Axons branch to innervated multiple fiber -Each muscle fiber is innervated by single synaptical terminal
Electrical conduction channels in heart
-Fast sodium channels -Slow calcium channels that open in response to change in membrane potential to specific threshold V (calcium moves down its gradient)
Pressure Volume (PV) Loop
relationship between pressure and volume of the hear chamber during the cardiac cycle constructed graphically from the corresponding moment-to-moment values of pressure and volume
Frank Starling Mechanism
-If heart muscles are stretched, will contract with more force and increase venous return (return blood to heart from vena cava) = heart fills more -Muscle fibers stretch and contract more forcefully and you get a larger blood volume
How is circulation through a capillary bed regulated
blood flows to parts of the body where it is needed most Precapillary sphincter relax to allow blood to enter the capillary bed
Hemmorhage results in...
loss of blood volume and decrease in blood pressure
Cardiovascular System Regulation
exercise increased cardiovascular performance to support enhances oxygenation of blood at the lungs
the physiological response to hemorrhage includes..
immediate hypercardia and generalized vasoconstriction to restore blood pressure supporting oxygen delivery to essential
Central Cardiovascular system Regulation
functions of cardio and ventilatory interrelated since changes in oxygen demand will be met by altered activity of both systems
Corneille Heymans
first described physiology of vascular system chemo-receptors and baroreceptos that can modulate CNS regulatory activity
Chemoreceptors
respond to chemicals cardiac bodies and the aortic bodies are chemoreceptors for Oxygen, carbon dioxide and hydrogen
hyperemia
increased blood flow
ischemia
decreased blood flow
Two most important gases from physioigists perspective
oxygen and carbon dioxide
Concentration (units in resperatory and metabolic physiology)
volume per volume(% at specific temp); quantity of gas (moles per volume, independent temperature)
Partial Pressure (unites in respiratory and metabolic physiology)
the proportion of the total atmospheric pressure of a gas mixture that is contributed by that gas
Mammal Respiratory Gas Transport System
Ventilation --> Uptake --> Circulation --> Delivery
Lung Ventilation
Tidal Ventilation
Gill Ventilation
active movement of fluid across a respiratpry surface
what does the swim bladder, seen in the bony fish, do?
allows them to regulate their buoyant density to remain suspended at any depth in the water effortlessly
Insect Tracheal System
Rigid air tubes that branch throughout body (air sacs and trachae) -Tracheoles reach every cell -->low diffusion distance -Ventilation: diffusion -Circulatory system not involved
Comparative Physiology
comparing and contrasting of physiological mechanisms, processes of responses across species, or within a single species under different conditions

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