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Lipid Metabolism
Burning Triglycerides to generate ATP
How much ATP does 1 glycerol produce?
12 ATP
How much ATP does 1 C-C fatty acid chain produce?
16
Burning fats yields about ______ times the yield of burning glucose.
1.5
Amino Acid Catabolism is bad because.....
1.)It I difficult for the body to burn amino acids 2.)Proteins are needed for other things 3.)Denaturing the amino acid is toxic
What are the 2 parts of the integumentary system?
Epidermis and Dermis
What is the epidermis made of?
Stratified squamous epithelium
What is the dermis made of?
Areolar Connective Tissue
What are the 2 layers of the dermis?
1)Papillary 2.)Reticular
What does the Papillary Layer consist of?
Areolar connective tissue with a lot of elastin in it
What does the reticular layer consist of?
Areolar Connective tissue
Is the hypodermis part of the integumentary system?
No
What does the hypodermis consist of?
Adipose connective tissue
What are the functions of the skin?
1.)Protection against foreign invaders 2.)Maintains body temperature 3.)Excretory gland 4.)Sensory Functioning 5.)Vitamin D Production
Stratum Germinativum (=basale)
-deepest skin layer -consists of cells actively undergoing mitosis -from this layer, cells move up and out over about 15-30 days -cells are strongly attached to each other by desmosomes -forms a barrier
Stratum Spinosum
-As the cells move up and out, they become polyhedral in the shape -they begin to form particles of keratin and keratohyalin
Stratum Granulosum
-Outermost living cell layer -Granules of keratin and keratohyalin "take over" cytoplasm -Cells begin to die because they have moved so far from the capillaries in the papilla of the dermis -nucleus disintegrates
Malpighian Cells
-Compose the stratum germinativum that divides and move up and out over 15-30 days
Melanocytes
-Found mostly in the stratum Germinativum -They have long, branchy processes that extend up and between malpighian cells
Which amino acid kicks off the production of melanin?
Tyrosine
What is the melanin enclosed in?
Melanosomes that are produced by the Golgi apparatus
What is the shape of the melanocytes found in redheads?
round
What is the typical shape of melanocytes?
Oval
What makes the melanocytes in Africans different?
They are slightly longer with more pigment (not more melanocytes)
Langerhan Cells
-Found in stratum spinosum and stratum granulosum -Lo0k like melanocytes -are actually phagocytic cells of the skin -wander around looking for invaders and engulf them -true dendritic cells -especially important for infections of the skin, like HIV and AIDS
What happens to the Langerhan cells when using drugs?
Dendritic cells are suppressed
Merkel Cells
-Found in the stratum germinativum -do not undergo mitosis -Associated with the free nerve ending in the papillae -specialized mechanoreceptors for shape and texture
Stratum Lucidum
-Cells die in stratum granulosu, and release the contents into this -layer consists of dead, empty husks
Stratum Corneum
-Piece and strands of dead cells are compressed -lots of keratin, which provides waterproofing -constantly sloughing off, taking bacteria and viruses with it
What are the functions of the Papillary Layer?
-Consists of the papillae, which are little invaginations -have lots of capillaries and meissner's corpuscles
What are Meisner's Corpuscles?
Receptors of light touch
What are the functions of the Reticular Layer
-Deeper and much wider than the papillary layer -consists of a network of fibers running in all different directions -sweat glands, hair follicles, and sebaceous glands are also found here
What is another name for a sweat gland?
Sudoriferous Glands
Sympathetic Nervous System
-fight or flight -fire when you become aroused
What are the 2 kinds of sweat glands?
1.)Eccrine glands 2.)Apocrine glands
What is an eccrine gland?
-Secrete through Merocrine secretion -found in entire body except lips and genitalia -stimulated by heat and nervous, produces sweat for cooling
What is an apocrine gland?
-Actually secretes through Merocrine secretion -found in axilla and genitalia
What do the 2 kinds of sweat glands secrete?
-Water -Salt -pheromones -urea -uric acid -phosphates -lactic acid -ascorbic acid
Cercuminous Glands
Exist in the ear canal and manufacture ear wax
Mammary lands
Produce milk
Hair follicle
Consists of the 2 living layers of epidermis cells folded deep into the dermis -hairs are compressed dead cells -keratin, keratohyalin, and pigments that are made by the hair follicle make the hair to be sort of the same as stratum corneum
Arrector Pili Muscle
-Erect the hairs of the body to increase insulation -cause goosebumps
Sabaceous Glands
Coat the hair and make it supple
How fast do fingernails grow per day?
.01 mm
How fast do toenails grow per day?
.005 mm
What does the Central Nervous System consist of?
-Brain -Spinal Cord
Peripheral Nervous System
-all of the nerves outside the CNS -13 cranial nerves -31 spinal nerves
Afferent Division
-incoming or sensory part of the PNS
Efferent Division
-Outgoing or motor part of the PNS
What are the 2 kinds of the efferent division?
1.)Somatic Nervous System 2.)Autonomic Nervous System
Somatic Nervous System
-Controls the contraction of the voluntary skeletal muscles of the body
Autonomic Nervous System
-Regulates the blood vessels, smooth muscles of the gut, cardiac muscles of the heart, and the glands
What are the 2 kinds of the Autonomic Nervous System?
1.)Sympathetic  2.)Parasympathetic
Sympathetic
-fight or flight
Parasympathetic
-fires when you are not threatened -promotes digestion and digestion -rest and rumination system
What are the 2 types of nervous system cells
1.)neurons 2.)neuroglial cells
What are the 6 kinds of neroglial cells?
1.) Schwann Cells 2.) Satellite Cells 3.)Astrocyttes 4.)Oligodendrocytes 5.)Microglia 6.)Ependymal Cells
What is the cytoplasm of the neuron cells made up of?
Organelles and nissl substance, many pigments, and lipofuscin
Unipolar Neuron
No dendrites, only a single axon sticking out of the cell body, common in embryos and fetuses, rare in adults
Schwann Cells
Wraps neurons either loosely or tightly in PNS
Oligodendrocytes
-Wrap neurons either loosely or tightly in CNS
Astrocytes
-Found in the CNS -Provides framework for neurons and capillaries -Form the blood brain barrier -regulate nutrients and wastes that go to and leave the neurons
Satellite Cells
-Sort of the astrocytes of the PNS -they certainly provides a structural framework -they seem to regulate what passes from blood to neuron -less effective -implicated with chronic pain syndrome
Ependymal Cells
-Line the cavities of the CNS -Ventricles of the brain and central canal of the spinal cord -produce cerebral spinal fluid
Microglia
-Found in the CNS -Phagocytic cells for foreign invaders in the CNS and ingest and eat damaged neural tissue
What are the 2 kinds of synapses found in humans
1.)Chemical Synapse 2.)Electrical Synapse
Chemical Synapse
-A synapse that uses a chemical neurotransmitter to cross a synapse
Electrical Synapse
-Gap junction is used or a nexus -pretty rare, found deep in brain -uses electricity to bridge the synapse by using a gap junction between neurons
What are the 2 kinds of chemical neurotransmitters?
1.)Excitatory neurotransmitters 2.)Inhibitory neurotransmitters
Excitatory neurotransmitters
-causes depolarization and promote an action potential in the post-synaptic neuron
Inhibitory Neurotransmitters
-causes hyperpolarization and inhibit an action potential in the post synaptic neuron
Step 1 of the action potential
the action potential of the pre-synaptic neuron arrives at the end bulb
Step 2 of the action potential
opens protein channels for the Ca+, Ca+ rushes in to the end bulb of the neuron
Step 3 of the action potential
this Ca+ influx causes vesicles with neurotransmitters to move to the cell membrane inner surface and release the neurotransmitter by exocytosis
Step 4 of the action potential
the neurotransmitter chemical crosses the synapse and binds to receptor proteins on the post-synaptic neuron surface
Step 5 of the action potential
Causes an action potential to form in the post-synaptic neuron surface
Step 6 of the action potential
Neurotransmitter is quickly broken down by the enzyme
Are synapses unidirectional?
yes
What are some other chemicals made and released at the synapse that are not neurotransmitters?
Neuromodulators
Neuromodulators
can modulate a response of the post synaptic neuron
What is the most common kind of neuromodulators?
Opioids like endorphins

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