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How much blood in avg. adult
5
Formed elements
Erythrocytes Leukocytes Platelets
Plasma composes _% of blood
55%
How much plasma is water
90-92% Remainder is dissolved substances
3 plasma proteins
Albumin Globulin Fibronogen
Albumin
Helps transport fatty substances
Globulin
3 types
Fibrinogen
blood clotting protein
Gives blood red color
Hemoglobin (Hgb, Hb)
RBC per cubic mm of blood
5 million RBC
Avg adult has _ RBC
35 trillion RBC
_ has more RBC
Males
RBC life span
120 Days
RBC's bring
oxygen to body tissues
Essential nutrients for RBC synthesis
Iron Folic acid Vitamin B12
Anemia
Conditions that decrease RBCs
hypoxia
lack of oxygen
Iron Deficiency anemia
Most common cause of anemia worldwide
w/o enough iron, body fails to synthesize
hemoglobin
Symptoms of iron deficiency anemia
craving for ice swelling of the tongue dry lips
Reduction in RBC is called
hypochromia
Vitamin C
enhances iron absorption
IDA in pregnant of developed nations
23%
IDE in pregnant women in developing nations
52%
IDE Pre-school Developed
20%
IED pre-school developing
39%
severe anemia is considered
40% of pregnant population
Anemia of Chronic Disease
2nd leading cause of anemia
Intrinsic factor
A deficiency in a specific protein
intrinsic factor is produced
in stomach & B12 is absorbed in the small intestine
Pernicious anemia aka
Vitamin B12 Deficiency Anemia
Vitamin B12 deficiency anemia
without b12 & intrinsic factor, membranes of immature RBC rupture easily in blood stream
Etiology of Pernicious anemia
Inadequate diet Increased requirements & excretion of B12 Strict vegetarianism
What 2 B12 foods can be eaten by vegetarian
Bran & tofu
Symptoms of pernicious anemia
abdominal distress: nausea/vomit Burning of tongue Neurological disturbances
b12 supplementation necessary for
Strict vegetarians Chronic bowel disorders Stomach/bowel removed
Folic acid deficiency anemia
in West Low consumption of raw fruits/veggies
Folic acid deficiency anemia at-risk
pregnant/lactating alcoholics kidney diseased
Hemolytic anemia
reduction in circulating RBC caused by destruction of red blood cells Increased serum levels of bilirubin
Polycythemia
RBC mass is increased 2 types
Relative polycythemia
due to loss of plasma volume
Absolute polycythemia
aka: polycytma vera A rise in RBC mass + increase in WBC & platelets
Bleeding disorders aka
Hemostasis
Hemostasis
result from platelet dysfunction/deficiency, vitamin K deficiency, & clotting factor deficiencies
Disorders of Hemostatis
Thrombocytopenia Iodpathic Thromboytopenic Purpura
Thrombocytopenia
smal # of platelets can cause spontaneous hemorrhages can be corrected by treating underlying cause
Idiopathic Thrombocytopenic Purpura
Excess destruction of platelets Common in kids <5 Can be resolved in a few weeks if treated promptly
Neutropenia
Reduction of circulating neutrophils complication after chemo treatment depends on cause & severity
Idiopathic hypereosiophilic syndrome
increase in eosinophils produces congestive heart failure, valvuar disfunction
Onset of idiopathic hypereosinophilic syndrome
20-50 in males

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