Bio 212 Pre lecture Quiz 10 Endocrine pathophysiology 1 How is the pituitary gland and hypothalamus assessed for function Imaging and radio immunoassay methods assessment of baseline status of target cell hormones involves measuring serum cortisol serum prolactin serum thyroxine TSH serum testosterone estrogen serum GH plasma urine osmolality 2 How is hypopituitarism treated Treat underlying cause hormone deficiencies be treated cortisol replacement thyroid replacement sex hormone replacement 3 What are the clinical manifestations of acromegaly Enlargement of small bones of the hands and feet and membranous bones of the face and skull broad bulbous nose protruding lower jaw slanting forehead splayed teeth deepening of voice and development of bronchitis hunchback degenerative arthritis of spine hips and knees organ size increase 4 What is precocious puberty Early activation of the hypothalamic pituitary gonadal axis resulting in the development of appropriate sexual characteristics and fertility 5 Define myxedema Presence of nonpitting mucous type of edema caused by an accumulation of hydrophilic mucous polysaccharide substance in the connective tissues throughout the body 6 What is dangerous about myxedema Can turn into myxendematous coma a life threatening end stage expression of hypothyroidism characterized by coma hypothermia cardiovascular collapse hypoventilation and severe metabolic disorders 7 How is hyperthyroidism treated Eradication of thyroid gland with radioactive iodine surgical removal of gland use of drugs to decrease thyroid function effects 8 What are the manifestations associated with Cushing Syndrome Protruding abdomen subclavicular fat pads on back round face muscle weakness thin extremities stretch marks thinning of skin on legs and forearms osteoporosis
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