Bio 212 Pre lecture Quiz 13 Skeletal Pathophysiology 1 Describe osteogenesis imperfecta Heredity disease characterized by defective synthesis of type 1 collagen 2 What are risk factors for osteoporosis Advanced age female white small bone structure postmenopausal family history sedentary calcium deficiency high protein diet excessive alcohol caffeine smoking aluminum containing antacids anticonvulsants heparin corticosteroids gastrectomy diabetes mellitus chronic obstructive lung disease malignancy hyperthyroidism hyperparathyroidism rheumatoid arthritis 3 Differentiate between osteomalacia and rickets Osteomalacia bone condition in which there is inadequate mineralization of bone Rickets metabolic bone disorder characterized by failure or delay in calcification of cartilaginous growth plate in children whose epiphyses have not yet fused 4 What are the clinical manifestations of Paget s Disease Headaches intermittent tinnitus vertigo hearing loss collapse of anterior vertebrae bowed femur tibia softening of femoral neck sacral iliac bones pain stiffness weakened distorted bone structure 5 What are the manifestations of rheumatoid arthritis Fatigue anorexia weight loss joint aching stiffness joint dislocation 6 Describe the etiology of systemic lupus erythematosus Formation of autoantibodies and immune complexes B cell hyperreactivity and increased production of antibodies against self
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