Genetic testing analysis of the DNA to observe genes Results can lead to pre symptomatic treatments Hypertrophic cardiomyopathy Genetic tests available for that Genetic test for Huntington s disease get extra repeats can confirm the diagnosis The DNA sequences with other people are largely identical any nucleotides Genetic variation can change proteins which lead to changes in genotypes A and T are two different variants Variant 1 hemoglobin gene a no sickle cell anemia not resistant to malaria Variant 2 t sickle cell anemia resistant 3 major types of genetic variations SNP change in one DNA nucleotide Insertion insertion of one or more DNA nucleotide in a genome Deletion deletion of one or more DNA nucleotides PCR amplify a short sketch of dna 1 st make copies heated denature decreased bind polymers copied higher temp add nucleotides to extend make additional copies after 3 cycles target sequence accumulates primer binds right outside of the sequence Gel electrophoresis dna molecules divided by the size and charge Insertions and deletions detected by pcr Single nucleotide polymformasim Relp analysis restriction enzymes recognizes sequence cut dna run it on the gel two pieces of shorter dna ex sickle cell homeglobin longer for restriction enxymes to cut Snps and insertionas deletions can be identified by conventional Dna sequencing very expensive 10 2 13 Genome sequencing make copies then reassemble it the price has fallen too advantages can tell heriderity genes Pcr and electropgerisis deletions Relp a single nucleotide 10 9 13 Domainat or recessive use family pedigrees homo both alleles r the same hetro genes are different Sex linked disourders more males or females are affected y linked all the mens r affected fathers will pass it to all of their sons
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