GENE 412 1st Edition Lecture 1 Outline of Last Lecture I First Lecture No Last Lecture Outline of Current Lecture II Hardy Weinburg Equation A Hardy Weinburg Assumptions B Population Assumptions for Hardy Weinburg III Different Ways to be an Allele IV Allele Frequencies for Future Generations Current Lecture I Hardy Weinburg Equation a Rediscovery of Mendelian Genetics i Variation leads to Mendelian Genetics b Given alleles A a at frequencies p q after one generation the population will produce genotype frequencies p2 AA 2pq Aa q2 aa c Equations for Hardy Weinburg i p2 2pq q2 1 ii p q 1 d Hardy Weinburg Assumptions i No Migration very important ii No selection 1 Evolution A change through time of the various types of genes or gene combinations in the gene pool iii No Mutation iv Large population size essential e Population Assumptions for Hardy Weinburg i Sexual ii Diploid iii Non overlapping genes II Different Ways to be an Allele a Different primary gene sequence i Different RNA from original RNA These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute b Indel s i Insert or deletion of a nucleotide in DNA c Inversions i Leads to changes in expression levels III Allele Frequencies for Future Generations a If Hardy Weinburg Assumptions are met then allele and genotype frequencies persist in the population generation after generation b Example of Hardy Weinburg Question i Allele Frequencies 1 A 8 2 A 2 A 8 a 2 A 8 AA p2 64 Aa pq 16 a 2 Aa pq 16 aa q2 04 i Follows the equation a 64 p2 16 pq 16 pq 04 q2 1