GENE 412 1st Edition Lecture 6Outline of Last Lecture I. How D Changes over time II. Example of D (Recombination) ProblemOutline of Current Lecture I. Recombination FrequencyII. Introduction to Inbreeding Current LectureI. Recombination Frequency a. AB/ab – Only class that can produce Abb. Is aa good marker for bc. From previous lecture; D3 = 1/6 i. This value shows that a is NOT a good marker for b because 1/6 is too small ii. For it to be a good marker, D’ would be a lot closer to 1 iii. Perfect marker D’ equals exactly 1d. Test Cross dataA B Parental A b Recombinanta B Recombinant a b ParentalII. Introduction to Inbreeding a. F = inbreeding coefficient i. Produced by Malecotb. Inbreeding – Probability of homozygosisty by descent of an allele from a common ancestor c. F = P(aa) by descent = ½ selfing, ¼ sibling mating, 1/8 half sibling/uncle niece, 1/16 cousin d. Make sure to go over basic Pedigree rulese. F(A1A2) = ½i. P(A1A1) or P(A2A2) or P(A1A2) or P(A2A1)These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.ii. 1/2*1/2+ 1/2*1/2+1/2*FA = 1/2 (1+FA) = 1/2 (1+(1/2)) =