GENE 412 1st Edition Lecture 8Outline of Last Lecture I. Calculating a path with multiple paths II. X-linkedIII. The consequence of consanguinityOutline of Current Lecture I. What does inbreeding do?II. How inbreeding relates to evolutionIII. Difference between F & fIV. ExamplesCurrent LectureI. What does inbreeding do?a. Genotypic level-changes genotype so dramatically but does it change allelic frequency II. How inbreeding relates to evolutiona. Inbreeding is not an evolutionary force i. Doesn’t change ALLELE frequencyii. p = .6 & q = .4iii. Inbreed population completely means to distribute alleles to homozygotes1. Does not affect variation of alleles in populationiv. p = .6 & q =.41. P1 AA Aa aa.36 .48 .16F1 AA Aa aa.6 0 .4b. f = correlation of uniting gamationi. -1<f<1ii. f = (HeterozygotesExp for H.W. – Observed Heterozygotes)/ HeterozygotesExp for H.W.These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.III. Differences in F inbreeding coefficient and f inbreeding coefficient F- Specific Individual- Probability of homozygosity- 0<F<1- Identity by descent (pedigree)f- Local population- Correlation coefficient- -1<f<1- System of mating- Defined by deviation from expected H.W. genotype frequenciesIV. Examples a. 1969-1972i. observed Heterozygotes (Hets) in a small inbred population of gazelles1. obs. Hets =.5 2. Expected Hets =.3753. (.375-.5)/.375=-1/34. The reason f is negative with such an inbred population is the breeders were intentionally trying to mate least related individuals5. Bottom line: Picking a mate in a population that is the least relatedto you will give you a negative f
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