GSU NEUR 3000 - NEUR 3000 - Chapter 6 (37 pages)

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NEUR 3000 - Chapter 6



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NEUR 3000 - Chapter 6

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Pages:
37
School:
Georgia State University
Course:
Neur 3000 - Hon Principles of Neuroscience

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NEUROTRANSMITT ER SYSTEMS NEUR 3000 Dr Joseph J Normandin PRINCIPLES OF NEUROTRANSMITTER SYSTEMS There are three classes of neurotransmitters Amino acids Amines Peptides there s probably more Within these classes there is a multitude of neurotransmitters Each neurotransmitter is part of a system that includes The molecule itself Synthesis of the neurotransmitter Packaging Reuptake degradation Action PRINCIPLES OF NEUROTRANSMITTER SYSTEMS There are three criteria that define a neurotransmitter Synthesis and storage in presynaptic neurons Released by a presynaptic axon terminal Produces a response in a postsynaptic cell Neurotransmitters bind to specific receptors There are many receptor subtypes for a given neurotransmitter Receptors can be transmitter gated ion channels ionotropic or g protein coupled receptors metabotropic The receptor determines neurotransmitter action A given neurotransmitter can have opposing actions depending on the receptor PRINCIPLES OF NEUROTRANSMITTER SYSTEMS PRINCIPLES OF NEUROTRANSMITTER SYSTEMS Exogenous molecules also interact with neurotransmitter receptors Any compound that binds to a receptor is a ligand Exogenous ligands that mimic the effect of a neurotransmitter are called agonists Exogenous ligands that block the effects of a neurotransmitter are called antagonists PRINCIPLES OF NEUROTRANSMITTER SYSTEMS PRINCIPLES OF NEUROTRANSMITTER SYSTEMS Neurotransmitter systems are defined by neurons that release a particular neurotransmitter Dopaminergic neurons GABAergic neurons However a given amine or amino acid neurotransmitter system may also co release with peptide neurotransmitters NEUROTRANSMITTER CHEMISTRY Acetylcholine ACh Amine neurotransmitter Cholinergic neurons Found in Motor neurons of the neuromuscular junction Central nervous system Autonomic nervous system NEUROTRANSMITTER CHEMISTRY NEUROTRANSMITTER CHEMISTRY NEUROTRANSMITTER CHEMISTRY Acetylcholine ACh In Alzheimer s disease there is death of CNS ACh neurons Drugs that



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