Genetic Disease 4-Part Assignment –Significant part of overall Course Grade!!(Rubric sums to 200 points)!(Groups of 3-4)!!•Use Google Docs to work on all parts of this assignment as a group – you must invite your instructor to be a group member on the document. This allows your instructor access ongoing work and will be used if there are any questions regarding group member contributions. Instructions on how to use Google Docs are on the course home page via the References and Writing link!•Save final documents for each part of the assignment as a .doc or .docx and submit to the D2L drop box for the separate assignment. Put all of your net ids in the file name as well as GenDisPart 1. Ex-ample: netID1_netID2_netID3_GenDis1.doc. INVITING YOUR INSTRUCTOR TO THE GOOGLE DOC DOES NOT COUNT AS TURNING IT IN. !•Fill out a group evaluation at the end of completing each part of the assignment. Make sure that these are included in the final documents you turn in. The entire assignment is a group assignment: everyone is expected to contribute equally and respond to other group members’ inquires about the ongoing work in a timely way. Work submitted individually does not meet the requirements of the assignment and will receive a zero!Information page to assist you in this work:! http://blc.arizona.edu/courses/181Lab/HowTos/Genetic_Disease_HowTo.html!!Part 1 (50 points):!!General description!a.) How many suffer from the disease? Any particular groups/geography?!b.) Did you come across any other names for the disease, gene or protein? List them. !c.) What are the symptoms?! d.) Many genetic diseases are the result of a protein not doing its job or doing its job incorrectly. What does the protein whose malfunction is responsible for causing the disease do when functioning normally? Be SPECIFIC with your answer. Any technical terms, jargon or medical vocabulary should be accompanied by an explanation or definition not containing technical terms. Your explanation should make sense to a high school student. ***Make sure you carefully examine the resources provided for your specific genetic dis-ease in the ‘How To’ link above***!e.) Explain how the decreased function of the protein gives rise to the symptoms of the disease. Your explana-tion to the extent possible, should have all the linkages between the failure of the protein and symptoms of the disease. Again, any scientific jargon, technical terms etc. must be explained.!f.) What are the treatments for the disease? How do treatments for the disease (if any) alleviate the symp-toms? You should integrate your answer from part (d). !!Your mutation !g.) What codon changed to what? If you cannot directly find this information, look at the initial amino acid and the resulting amino acid (the one due to the mutation). Use your codon table to deduce the codon changes necessary to go from the initial to resulting amino acid. Remember, the fewer the number of changes, the more likely it is to have been the case. !!h.) What are the properties of the wild type (initial) amino acid? (Properties include: charge, shape, size and flexibility, features unique to the amino acid {i.e. the ability of histidine to respond to pH values typically found in the body, etc.})!!i.) What are the properties of the mutant (resulting) amino acid? !!j.) How similar/different is the mutant amino acid from the wild-type?!!Source Evaluation!k.) For each of the above questions - What are your sources for the information? !! Include a formal MLA format citation for each source (this includes a parenthetical citation in the text of your answers such as this one: (1) which is dereferenced at the end of this document). Here is a link with general MLA instructions: . Here is a link with specific instructions for citing web pages: !http://owl.english.purdue.edu/owl/resource/747/08/ !For each source, write a sentence or two explaining:!! 1.) What information you got from this source!! 2.) How reliable you consider the source. i.e. brief description of who hosts the website, how recent the information is, any possible bias the website hosts may have and the quality of the references (if any) the site uses!!! !!!AspectExpectationLoss of credit if:Sufferers (2.5)Meaningful explanation of how widespread the disease is!Accurate commentary on distributionInaccurate or incomplete information.Symptoms (2.5)Easy-to-understand, clear and completeUnexplained technical terms; not presented in everyday, non-medical English.Normal function of protein (5)A non-technical description of the role the protein normally plays in cells. Unexplained technical terms; not presented in everyday, non-medical English.!Specific role of the protein not described. Explanation concerning how symptoms arise (10)Explanation of why the absence of the protein or its misbehavior results in the genetic disease. Unexplained technical terms; not presented in everyday, non-medical English.!!Incomplete logical chain. Treatments (5)A non-technical description of the treatments and why they work. Unexplained technical terms; not presented in everyday, non-medical English.!Missing an explanation/conjecture about why treatments work, or why it is unknown as to why they work.Source evaluation (10)Clear, complete information on where you found out what you learned.!Thoughtful consideration of reliability of the source (and whether it is what it claims to be)Evaluation overly trusting; original source(s) not cited in MLA format. Parenthetical, in-text citation is missing. Information retrieved from source not summarized. Reliability of source not evaluated. Codon change (5)Specific codon change and source of information, or deduced possible changes based on amino acid changeIncorrect or not possible based on sequence; invokes more changes than requiredAmino acid change (10)Correct; includes amino acid name and 3-letter representation !Properties of both briefly stated!Comparison of the two amino acids includedNeedlessly wordy; technical terms not defined (none are required)Part 2 (50 points) [details not finalized until assigned]: !This section is to be based on your own, original analysis, NOT research you do online. Re-search should only be done to supplement you're analysis (to clarify small points). Signifi-cant loss of credit will result if your analysis is based primarily on outside research. !! Depending on your particular protein and the components present