BIBC 100 STRUCTURAL BIOCHEMISTRY SPRING 2007LECTURE: Tuesday and Thursday 8:00 – 9:20 A.M.Price TheaterINSTRUCTORS: M. Montal (x40931)Office Hours: Thursday 9:30 – 10:20 AMPacific Hall, Room 3501Sutara Tang ( x41654)(Project Assistant) Room 1100C, Pacific HallDATEAPR Tues 3 Thurs 5 Tues 10 Thurs 12 Tues 17 Thurs 19 Tues 24 Thurs 26 MAY Tues 1 Thurs 3 Tues 8 Thurs 10 Tues 15 Thurs 17 Tues 22 Thurs 24 Tues 29 Thurs 31JUNE Tues 5 Thurs 7TOPICSTRUCTURAL PRINCIPLESBasicsExploring ProteinsMotifsMotifsDNA/RNANMR/X-RayNMR/X-RayRECOGNITIONProtein-DNAImmune SystemMID-TERM IN CLASSENERGY & SIGNALTRANSDUCTIONMembranesMembrane ProteinsChannelsReceptorsReceptorsDYNAMICSCa 2+ and Oxygen BindingCATALYSISProteasesProteasesFOLDING AND DESIGNFolding and DesignFolding and DesignBRANDENAND TOOZECHAPTER123,45718188,1015121212131331111617ASSIGNEDPAPER#1#2#3#4#5BUEHLER’SREADERCHAPTER1.11.21.31.31.41.81.83.23.61.72.52.43.73.72.22.12.12.62.7FINAL EXAM MONDAY, JUNE 11 8:00 – 11:00 A.M.BIBC 100SPRING 2007Textbooks (required): Introduction to Protein Structure. C. Branden andJ.Tooze, 2nd Edition. Garland Publishing Co., NY1999.Kinemage Supplement to Branden and ToozeJ.S. Richardson and D.C. RichardsonGarland Publishing Co., NYReader: Structural Biochemistry, 2nd Edition. Lukas BuehlerWiley Custom Services, 2002.Class Websites: http://www.biology.ucsd.edu/classes/bibc100.SP07Useful Websites: http://www.ncbi.nlm.nih.gov/gquery/gquery.fcgiCourse Requirements: GRADEMidterm: Thursday, May 3, during class 40%Final: Monday, June 11, 8:00 – 11:00 A.M. 60%ASSIGNED PAPERS – Synchronized with the syllabus#1 From SCIENCE Vol. 286, ©October 8, 1999: pp. 255-260 “Structural Changesin Bacteriorhodopsin During Ion Transport at 2 Angstrom Resolution”, by Luecke,Schobert, Richter,et al.#2 From NATURE Vol. 423, ©May 2003: pp. 33-41 “X-ray Structure of a Voltage-Dependent K + Channel” by Jiang, Lee, Chen, et al.#3 From NATURE Vol. 423, ©June 26 2003: pp. 949-955 “Structure and GatingMechanism of the Acetycholine Receptor Pore” by Miyazawa, Fujiyoshi, Unwin.#4 From NATURE Vol. 427, ©January 1, 2004: pp. 36-44 “X-ray Structure of aProtein-conducting Channel” by Vandenberg, et al.#5 From SCIENCE Vol. 302, ©November 21, 2003: pp. 1364-1368 “Design of aNovel Globular Protein Fold with Atomic-Level Accuracy”. pp. 1347-1348“Learning to Speak the language of Proteins” by Kuhlman, Dantas, Ireton, et al.Graduate Student T.A.:Matthew [email protected] Student T.A.s:Rachel Newman – [email protected], 925-788-2669Christopher Rafie – [email protected], 925-698-9276Artour Torossian – [email protected], 818-822-7270POLICY ON REGRADES:Regrades: If a student considers that their exam was not properly graded, theymay turn in the unaltered, complete exam for a regrade to the TAs no later than 1week after the exams become available for pick-up. Students must write up on aseparate sheet attached to the exam which questions they consider requireregrading and sign the bottom of this sheet.Students are responsible for understanding that, by requesting a regrade,the entire exam in addition to the indicated questions will be re-evaluated,and points may be added or taken away as a result.BIBC 100: STRUCTURAL BIOCHEMISTRYGRADING INFORMATION: Plus and minus grading will not be usedMIDTERM: Grade Revisions:Submit request to TA no later than May 10, 2007No grade changes after May 15, 2007NO EXCEPTIONSFINAL: Grade Revisions:Submit request to Professor or TA no later thanJune 18, 2007No grade changes after June 25, 2007NO EXCEPTIONSBIBC 100: Structural BiochemistryGuidelines for Class Etiquette During Examination1. All writing instruments must contain non-erasable ink. If students choose notto write in pen, they forfeit the opportunity for a future regrade.2. All books and handbags should be placed at the front or back section of theauditorium for the duration of the exam.3. Students should sit in alternating seats whenever possible.4. When time is called, anyone who is still writing will automatically receive azero for that page. THIS WILL BE STRICTLY ENFORCED. Remain in yourseat and hand your exam down the aisle.UCSD policy on integrity of scholarship (UCSD catalog 99-00, pages 72-74)and Rules of academic dishonesty will be strictly
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