Fig. 11-9 LehnSpearmintCinnamongi|10048448|ref|NP_065258.1| odorantreceptor MOR28 [Musmusculus]MEKAVLINQTSVMSFRLTGLSTNPKVQMAIFFIFLIFYVLTLVGNILIVVTIIHDHRLHTPMYFFLSNLSFIDVCHSTVTVPKMLSDTFSEEKLISFDDCVVQIFFLHLFACTEIFLLTVMAYDRYVAICKPLRYMTIMNWKVCMVLGGAMWTAGTIHSISFTSLTIKLPYCGPNELDSFFCDVPQVIELACTDTRITEILVVSNSGMISMVCFVIIVVSYAVILVSLRQQISDGKRKALSTCAAHLTVVTLFLGHCIFIYSRPAISLPEDKIVSAFFTAITPLLNPIIYTFRNEDMKSALKKLIRRKEGKEKAn activated odorant GPCR then activates a G-proteinG-proteins A) are dimers. B) hydrolyze GDP to GTP. C) exchange bound GDP for GTP. D) add Pi to GDP to form GTP. E) bind to single transmembranepass receptors.Fig. 11-20 LehnFig. 11-20 LehnHeterotrimeric G-protein structureLehn Fig 12-14B and T Fig. 13.7Green - GTP bound (on)Blue - GDP bound (off)Active and inactive Galpha subunitsB and T Fig. 13.8 Hydrogen bonds are red dashed lines.Conformational changes resulting from the presence or absenceof a terminal (gamma) phosphate.“off”“on”Note the movement of R201, R204, E232 and E241 sidechains.B and T Fig. 13.7Green - GTP bound (on)Blue - GDP bound (off)Active and inactive Galpha subunitsB and T Fig. 13.7Green - GTP bound (on)Blue - GDP bound (off)Active and inactive Galpha subunitsFig. 13-2 B and TAn activated G-protein then activates adenylyl cyclaseFig. 13-3 B and THormones, such as epinephrine, also activate adenylyl cyclase.Fig. 12-12LehnFig. 12-15 LehnFig. 12-16LehnProtein Kinase A (PKA)Huse and Kuriyan, 2002The PKA structure has twomain lobes (subdomains).Huse and Kuriyan, 2002Schematized PKA structureHuse and Kuriyan,
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