1Immunoglobulin structure and antigen recognitionCox, Lehninger Principles in Biochemistry, chapter 7, figure 23X-ray structure of Immunoglobulin G (IgG)2Voet&Voet, Biochemistry, 2nd ed., chapter 10, figure 29Sample structures of N-linked oligosaccharides found in animal glycoproteins as well as viral envelopesX-ray structure of Immunoglobulin G (IgG); Cox, Lehninger Principles in Biochemistry, chapter 7, figure 23Voet&Voet, Biochemistry, 2nd ed., chapter 10, figure 29Core structure of N-linked oligosaccharide3Cox, Lehninger Principles in Biochemistry, chapter 7, figure 23Domain structure of Immunoglobulin G (IgG)Class Heavy chain light chain IgA α κ or λ IgD δ κ or λ IgE ε κ or λ IgG γ κ or λ IgM µ κ or λ Immunoglobulin subunit nomenclature4Voet&Voet, Biochemistry, 2nd ed., chapter 34, figures 21, 24Amino acid variability in complementarity determining regions (CDR)Voet&Voet, Biochemistry, 2nd ed., chapter 34, figure 36Immune system receptors5T-cell receptor – MHC complexCox, Lehninger Principles in Biochemistry, chapter 7, figure 21X-ray structure of human class I MHC protein6Fig. Peptide binding to MHC class II domains (from Ghosh et al., 1995)Crystal structure of T-cell receptor -MHC I complex at 6 Å resolutionPurified and deglycosylated N15 T-cell receptor (top portion, variable domains Vαand Vβ and constant domains Cα and Cβ) was complexed with peptide loaded murine MHC class I (lower portion, domains labeled α1, α2, α3 and β2 microglobulin). Note that transmembrane domains have been cleaved off for crystallization purposes. The octapeptide (see text) is entirely buried in the TCR-MHC interface (arrow).(from Teng,
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