PHARMACOLOGY OF ANXIOLYTIC SEDATIVE HYPNOTICS Philip G Janicak MD Professor of Psychiatry Rush University I II Introduction A Anxiety is a natural human experience that can be crippling when excessive B Anxiety often complicates various medical disorders C Anxiety disorders have a lifetime prevalence of about 30 Tables A Anxiolytics B III IV Sedative Hypnotics Pharmacodynamics of Anxiolytics and Sedative Hypnotics A Overview B Gamma amino butyric acid GABA Function GABAA Chloride Ion BZD complex BZD receptor types BZD receptor activity Non BZD agents C Serotonin 5 HT Function 5 HT receptor subtypes Serotonin agents D Norepinephrine NE Function NE receptor subtypes Anxiety related and Sleep Disorders A Indications for Antianxiety Sedative Hypnotics B Generalized Anxiety Disorder GAD Represents 50 of anxious patients seen by physicians Treatment Strategy V VI C Obsessive Compulsive Disorder Symptoms Treatment Strategy D Sleep Disorders Types dyssomnias parasomnias Treatment Strategy Pharmacokinetics Drug Interactions and Adverse Effects of Anxiolytics and Sedative Hypnotics A Benzodiazepines Pharmacokinetics Drug Interactions Adverse Effects Dependence B Buspirone Pharmacokinetics Adverse Effects C Antidepressants see notes for lecture on antidepressants References
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