CHEM 153A – Biochemistry: Introduction to Structure, Enzymes, and Metabolism Spring 2011 Instructor Rebecca Nelson, Ph.D. email: [email protected] phone: 310-825-1670 office: Geology 3613 Course website http://web.chem.ucla.edu/~rebecca/153A/ Textbook Nelson & Cox. Lehninger Principles of Biochemistry 5th Edition, W.H. Freeman, 2008. Teaching assistants Mark Grossman [email protected] Reza Malmirchegini [email protected] Dan McNamara [email protected] Megan Sjodt [email protected] Sara Weitz [email protected] Nicole Wheatley [email protected] Lectures 1) MTWF 10:00-10:50 am, CS 50 2) MTWF 11:00-11:50 am, CS 24 Please attend the lecture in which you are enrolled. Course mission statement To help students learn the fundamental ideas and language of biochemistry so that they may recognize, understand, and communicate sound science. Tentative lecture schedule WEEK DATE, DAY TOPIC PAGES IN TEXT QUIZZES & EXAMS 1 Mar 28 M Introduction & overview (skim 1-42 for review) 29 T Water, Acid-base chemistry 43-66 30 W Titration curves, Buffers Apr 1 F Amino acids 71-81 2 4 M Peptides and proteins 82-4, 113-5, 140-3, 145-8 Amino acids quiz in discussion this week 5 T Protein sequence (1°) and evolution 92-4, 102-6 6 W Protein conformation and 2° structure 115-128 8 F Protein folds and assemblies (3°, 4°) 129-131, 135-140 3 11 M Carbohydrates – mono & disaccharides 235-244 Carbohydrates quiz in discussion this week 12 T Carbohydrates – oligo and polysaccharides 244-265 13 W Lipids 343-363, 365-6, 513 15 F Membranes 371-375, 381-386 4 18 M Membrane proteins 375-380, 389-396 Fatty acids quiz in discussion Exam 1 Thurs, 4/21, 5-6:50 pm 19 T Methods in protein structure analysis 94-100, 122, 132-4 20 W Molecular binding and allostery 153, 155-7, 162, 164-5 22 F Myoglobin & hemoglobin 154-5, 157-160 5 25 M Hemoglobin: O2 binding and effectors 161, 163-4, 165-170 26 T Enzyme catalysis and classification 183-188, 495-501 27 W Mechanisms of enzyme catalysis 188-194, 210-211 29 F Mechanisms continued; Lysozyme 213-216 6 May 2 M Serine proteases 205-209 3 T Enzyme kinetics 194-201 4 W Kinetics of enzyme inhibition 201-204 6 F Enzyme regulation 220-228 7 9 M Metabolism 485-495, 569-577 Exam 2 Thurs, 5/12, 5-6:50 pm 10 T Energy currencies 501-511, 516-521 11 W Glycolysis 527-531 13 F Glycolysis 532-538 8 16 M Glycolysis 539, 551-558, 633-634 Glycolysis quiz in discussion this week 17 T Fermentation 546-551 18 W Pyruvate dehydrogenase complex 615-620 20 F Citric acid cycle 620-630 9 23 M Citric acid cycle 630-638 Cofactors quiz in discussion this week 24 T Oxidative phosphorylation 707-712, 512-516 25 W Electron transport 712-716 27 F Electron transport & shuttle systems 716-722, 731-736 10 30 M Memorial Day Holiday Citric acid cycle quiz in discussion this week 31 T ATP synthase 723-731 June 1 W Catch up &/or Q&A 3 F Catch up &/or Q&A Finals 5 Su Final Exam: 3-6 pmEnrollment and drop policies PTE numbers are not given out for chemistry classes. Students on the waitlist or not yet enrolled are usually able to get into the course (although there are no guarantees). All students may attend lecture and discussion and take quizzes until their status is finalized. Students enrolled in a section that they cannot attend should use the course discussion board to find another student willing to swap enrollments (if the desired section is full). For enrollment questions or needs, see Denise Mantonya in the Chemistry Undergraduate Office, Young Hall 4009. Since this is an impacted course, students may freely drop only up until Friday of the 2nd week of the quarter. Requests to drop after this date require a sufficient reason and may or may not be approved. Academic honesty policy Any suspected problems involving academic honesty will be reported immediately to the Office of the Dean of Students. Quiz & exam policies Quizzes must be taken in the discussion section in which you are enrolled. No make-up quizzes or exams will be given, and exams will be offered only at the indicated times. Your lowest quiz score will be dropped. Regrade requests must be submitted to Dr. Nelson within two weeks of the return of the graded quiz or exam. (See the course website for further details, including quiz & exam coverage.) Exam scores will not be posted online or sent via email; you may pick up your exam in class. Grading 6 Quizzes, 10 points each = 50 points (lowest quiz score is dropped) 2 Evening exams, 100 points each = 200 points Final exam = 200 points Total = 450 points Grading Scale Grades are determined based on performance. The quality of student answers on exams will be considered, and score boundaries for grades will be determined based on this quality. Grade scales will be announced in class following the grading of each exam. If all students give high-quality answers, all students will receive A’s!Discussion Board – extra credit! Post questions &/or answers on the class discussion board to earn up to 10 extra credit points for the quarter. Earn up to 2 points every two weeks. See the course website for more info. Please note that I will not answer biochemistry questions over email – post these to the discussion board for your peers to answer, or ask in lecture, discussion, or office hours instead. Tips for succeeding in this course Attend lectures and discussions; arrive on time Read the textbook before the corresponding lecture Complete missing/unclear notes after lecture Seek help immediately if you don’t understand a concept Review your notes regularly Work through suggested problems and old exams Attend office hours regularly Use the discussion board for questions and review Review lecture podcasts as needed Keep up with the course; don’t procrastinate Start learning and reviewing today! First assignment: Learn how to learn Read the handout, “Learning (Your First Job),” and take the online Learning Style Survey, both of which are linked from the class website. (My survey results were: Visual/Verbal: 36; Visual/Nonverbal: 36; Auditory: 22; Kinesthetic: 20). How will you apply the suggested learning techniques to your study of biochemistry? Schedule of lectures, discussions, and office hours Monday Tuesday Wednesday Thursday Friday 8:00 OH – Dan, Young 5076 1C, Boelter 4413 –
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