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CHEM 153A – Biochemistry: Introduction to Structure, Enzymes, and Metabolism Winter 2010 Instructor Rebecca Nelson, Ph.D. email: [email protected] phone: 310-825-1670 office: Young Hall 3077B Teaching assistants Carly Ferguson [email protected] Domi Hodko [email protected] Alex Jacobitz [email protected] Catherine Leetola [email protected] Reza Malmirchegini [email protected] Khiem Tran [email protected] Huimin Zhang [email protected] Lectures 1) MTWF 9:00-9:50 am, CS 50 2) MTWF 11:00-11:50 pm, CS 24 Please attend the lecture in which you are enrolled. Textbook Voet, Voet, and Pratt. Fundamentals of Biochemistry: Life at the Molecular Level, 3rd Edition. Wiley, 2008. The shorter, customized text is sufficient for this course; consider buying the full text if you plan to take 153B/C. Course website http://web.chem.ucla.edu/~rebecca/153A Tentative lecture schedule WEEK DATE TOPIC PAGES IN TEXT QUIZZES & EXAMS* 1 Jan 4 M Introduction & overview 1-19 5 T Water 22-30 6 W Acid-base chemistry, Buffers 30-36 8 F Biomolecules and functional groups 4, 453 2 11 M Amino acids & peptides 74-89 Amino acids quiz in discussion this week 12 T Protein sequence 91-93, 104-120 13 W Protein structure 125-150 15 F Protein structure & function 151-165 3 18 M MLK Holiday Carbohydrates quiz in discussion this week 19 T Carbohydrates – mono & disaccharides 219-228 20 W Carbohydrates – oligo & polysaccharides 228-242, 544 22 F Lipids 245-259 4 25 M Membranes 260-278 Exam 1, Thu Jan 28, 5:00-6:50 pm 26 T Special topics &/or catch-up 27 W Molecular binding and allostery 193 29 F Myoglobin & Hemoglobin 176-186 5 Feb 1 M O2 transport by hemoglobin: effectors of oxygen binding 186-197 2 T Special topics &/or catch-up 3 W Biochemical reactions 5 F Enzyme catalysis 322-330 6 8 M Mechanisms of enzyme catalysis 330-339 9 T Lysozyme & serine proteases 339-360 10 W Special topics &/or catch-up 12 F Enzyme Kinetics 363-376 7 15 M President’s Day Holiday Exam 2, Thu Feb 18, 5:00-6:50 pm 16 T Kinetics of enzyme inhibition 377-385 17 W Enzyme Regulation 386-393 19 F Metabolism 448-459, 475-482 8 22 M Energy currencies 459-470 Glycolysis quiz in discussion this week 23 T Glycolysis 485-496 24 W Glycolysis 497-504, 510-515 26 F Fermentation 504-510 9 Mar 1 M Pyruvate DH Complex 566-576 Citric acid cycle quiz in discussion this week 2 T Citric Acid Cycle 576-583 3 W Citric Acid Cycle 583-594 5 F Special topics &/or catch-up 10 8 M Electron Transport 470-474, 596-618 9 T ATP Synthase 618-637 10 W Special topics &/or catch-up 12 F Q&A Finals 16 T Final Exam: 8-11 am, Location TBA * You must take quizzes in the discussion section in which you are enrolled. NO make-up quizzes or exams are given.Quiz & exam policies Quizzes must be taken in the discussion section in which you are enrolled. No make-up quizzes or exams will be given. Requests for regrades of quizzes or exams must be submitted in writing to Dr. Nelson within one week of the return of the graded quiz or exam. See the course website for further details and instructions. Please note that the whole quiz or exam may be regraded, so your score could be readjusted up or down. Academic honesty policy Any suspected problems involving academic honesty will be reported immediately to the Office of the Dean of Students. Grading Quizzes = 60 points 2 midterms, 100 points each = 200 points Final exam = 240 points Total = 500 points Grading Scale Grades are determined based on class performance. The quality of student answers on exams will be considered, and score boundaries for grades will be determined based on this quality. Grade scales will be announced in class following the grading of each exam. If all students give high-quality answers, all students will receive A’s! Discussion Board – extra credit! Post questions &/or answers on the class discussion board to earn up to 10 extra credit points for the quarter. Earn up to 2 points every two weeks. See the course website for more info. Please note that I will not answer biochemistry questions over email – post these to the discussion board or ask in lecture, discussion or office hours instead. Tips for succeeding in this course  Attend lectures and discussions; arrive on time  Read the textbook before the corresponding lecture  Complete missing/unclear notes after lecture, and review your notes regularly  Seek help immediately if you don’t understand a concept  Come to office hours regularly  Use the discussion board for questions and review  Use podcasts to review lecture discussions  Keep up with the course material… Don’t procrastinate! First assignment: On Learning  Read the handout, “Learning (Your First Job),” and consider how you will apply Dr. Leamnson’s suggestions in your study of biochemistry (and other subjects) this quarter.  Take the online Learning Style Survey to see how you learn best, and get study suggestions based on your personal learning style: http://www.metamath.com/lsweb/dvclearn.htm (My scores were: Visual/Verbal: 36; Visual/Nonverbal: 36; Auditory: 22; Kinesthetic: 20) Schedule of lectures, discussions, and office hours: Monday Tuesday Wednesday Thursday Friday 8:00 1A , Geology 4645 – Huimin 2A, Boelter 4413 – Catherine 1D, MS 5225 – Huimin 2C, MS 5233 – Catherine 1F, MS 6201 – Khiem 2F, Boelter 4413 – Catherine 1I, MS 5217 – Reza 2H, LaKretz 120 – Alex 9:00 Lecture 1: CS50 Lecture 1: CS50 2B, Boelter 5440 – Domi Lecture 1: CS50 2D, LaKretz 120 – Carly 1G, Boelter 5440 – Domi Lecture 1: CS50 OH - Carly, 3077F 10:00 OH - Domi, 3077F OH - Alex 3077F OH - Catherine, 3077F 11:00 Lecture 2: CS24 Lecture 2: CS24 Lecture 2: CS24 OH – (Rotating) 3077F Lecture 2: CS24 1J , YH 2200 – Alex 12:00 1K, MS 6201 – Reza OH (2 hrs), OH (1 hr), Dr. Nelson, 3077F OH (1 hr), Dr. N., 3077F 1:00 Dr. Nelson, 3077F 1B, Geology 6704 – Domi 2E, Pub Aff 2250 – Carly 1H, MS 6201 – Khiem 1L, MS 5217 – Reza 2I, MS 5225 – Alex 2:00 1C, Pub Aff 2270 – Huimin 1E, Young 1044 – Carly 2G, Pub Aff 2270 – Khiem 3:00 OH – Khiem, Boyer 436 4:00 OH - Reza, 3077F OH - Huimin, 3077F


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UCLA CHEM 153A - Syllabus

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