Chem 153C Metabolism and Its Regulation Winter 2001INSTRUCTOR: Prof. Sabeeha MerchantLECTURES: T, W, R, 8.00 - 8.50, 2200 YHTUTORIALS: M, 8.00 - 8.50, 2200 YHOFFICE HOURS:Prof. MerchantWeeks 1, 2, 3, 5, 6, 8, 9 Weeks 4, 7 (Exam weeks)T 9.00 - 9.50 AM Young 5070A T 9 - 10.50 AMW 9.00 - 9.50 AM Young 5070A W 9 - 10.50 AMIf it gets crowded, we will move to 1039 YoungOptions for communicating with Prof. Merchant about administrative matters. 1) See her after class in the Court of Science. 2) Go to office hours. 3) Leave a note in mailbox(3034 YH, mail and information desk). For option 3, reply will be pinned outside her office door. Options for communicating with Prof. Merchant about biochemistry. 1) Go to office hours. 2) Talk to her after class in the Court of Science.Teaching assistantsHui Cai Tobo LoaizaT 12.00 - 12.50 PM B-102 Young M 2.00 - 2.50 PM B-102 YoungR 1.00 - 1.50 PM B-102 Young W 11.00 - 11.50 AM B-102 YoungExtra hours will be announced for Mr. Aloiaza and Dr. Cai for the weeks of mid-term and finalexams. GRADING: 2 midterms (100 x 2) + 1 final (200) = 400 points. There will be no make-up examsoffered. The exams are scheduled in class, so it is expected that everyone can attend. Likewise, thefinal examination will be given as scheduled in the Final Examination Chart (p. 48 of Winter 2001Schedule of Classes) and it is expected that all students will take it at that time. OLD EXAMS: Exams from last year (no answers) are on reserve in the SEL/Chemistry library. Trythe exams and go to professor or TA office hours to verify your solutions. TEXT: Nelson and Cox, Lehninger Principles of Biochemistry, 3rd Edition. Specific readings willbe announced each week. Check “voh” if you miss announcements.HANDOUTS: A set of color-coded handouts will be available for each topic. Please bring theappropriate set to class until the topic is completed. Problem sets will be provided periodically.Answers will be posted on “voh”.LECTURE SCHEDULEWeek Date Topic1 Jan 8 Review of central metabolic pathways, Problem Set IJan 9 Review of principles of biochemical reactionsJan 10 Carbohydrate degradationJan 11 Glycogen synthesis2 Jan 15 HolidayJan 16 Gluconeogenesis, Glyoxylate pathwayJan 17 Pentose phosphate pathwayJan 18 Lipid degradation, Problem Set II3 Jan 22 Question and AnswerJan 23 Fatty acid oxidationJan 24 Ketone bodiesJan 25 Fatty acid biosynthesis, Problem Set III4 Jan 29 Question and AnswerJan 30 Deamination, transamination and cofactorsJan 31 Amino acid degradationFeb 1 Exam I (material through Jan 25)5 Feb 5 No meetingFeb 6 Urea cycle, Problem Set IVFeb 7 Principles of regulation of central metabolic pathwaysFeb 8 Mechanisms of regulation6 Feb 12 Question and AnswerFeb 13 Hormonal regulation, Problem Set VFeb 14 Meet the professorFeb 15 Nitrogen fixation7 Feb 19 HolidayFeb 20 Ammonia assimilationFeb 21 Question and answerFeb 22 Exam II (material through Feb 15)8 Feb 26 No meetingFeb 27 Amino acid biosynthesis, Problem Set VIFeb 28 Biosynthesis of physiological aminesMar 1 Isoprene pathway metabolism9 Mar 5 Question and AnswerMar 6 Sterol biosynthesisMar 7 Complex lipidsMar 8 Question and Answer10 Mar 12 Regulation of cholesterol metabolism, Dr. Peter EdwardsMar 13 Principles of photosynthesis; Calvin cycle, Problem Set VIIMar 14 “Light” reactionsMar 15 Regulation11 Mar 22 Final Exam, 8-11 AM
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