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Chem 153C Metabolism and Its Regulation Fall 2003 INSTRUCTORS: Prof. Carla Koehler TEACHING ASSISTANTS: Arun Divakaruni, Mui Sam LECTURES: M,T,W 1.00-1.50, Young Hall CS24 DISCUSSIONS: 1A R, 1.00-1.50, Young Hall CS24 1B F, 1.00-1.50, Young Hall CS24 OFFICE HOURS: Carla Koehler M, W 10-11 4041 Young Hall For weeks before exams, F 10-11 4041 Young Hall During Exam Week, a room will be scheduled if necessary Office hours will be scheduled as needed. If you need extra help, please also contact your teaching assistants. If many people are requesting help, the TA will schedule a time that fits his/her schedule. Extra office hours and locations will be announced for the weeks of mid-terms and final exams. Please check VOH for this information. Contacting your Instructors For administrative matters: for Dr. Koehler 1) See me after class. 2) Come to office hours. 3) Leave me a note in my mailbox (3034, mail and information desk). I can write a reply and leave it for you outside my office door or I can talk to you about it after class. 4) If necessary, via email. I prefer to send important announcements via email, but I prefer if students contact me after class or at office hours. For discussing biochemistry with Dr. Koehler, it is best if you come to office hours or talk to me after class. Use VOH for handouts and copies of problem sets, extra copies will be available in class if you miss them in class. To contact your teaching assistants: Go to discussions or talk with them after class Mui Sam [email protected] x62764 Arun Divakaruni [email protected] x65684 Bulletin Board for posting answers to exams is near Room 4064 Young Hall (near central elevators) Your CD has problem sets, lectures, and old exams. We will go over the problems in tutorials. GRADING: 2 midterms (100 x 2) + 1 final (200) = 400 points. There will be no make-up exams offered. The exams are scheduled in class, so it is expected that everyone can attend. Likewise, the final examination will be given as scheduled in the Final Examination Chart (Wed, Dec 10, 8-11 am) and it is expected that all students will take it at that time.LECTURE SCHEDULE Week Date Topic 0 Sep 25 Introduction by Dr. Koehler Sep 26 Introduction by TA Sep 29 Review General Concepts, (TA) Sep 30 Review of TCA cycle and Glycolysis (TA) Oct 1 Glycogen Metabolism Oct 2 Problem Set I (TA) Oct 3 Problem Set I (TA) 2 Oct 6 Gluconeogenesis Oct 7 Glyoxylate Cycle Oct 8 Pentose Phosphate Pathway Oct 9 Lipid Metabolism, Problem Set II(Koehler) Oct 10 Lipid Metabolism, Problem Set II (Koehler) 3 Oct 13 Fatty Acid Oxidation Oct 14 Ketone Bodies Oct 15 Fatty Acid Biosynthesis, Problem Set III Oct 16 Problem Set II/Review (TA) Oct 17 Problem Set II/Review (TA) 4 Oct 20 Deamination, Transamination Oct 21 Cofactors Oct 22 EXAM I (Material covered through Oct 15th) Oct 23 Problem Set III/Review (TA) Oct 24 Problem Set III/Review (TA) 5 Oct 27 Amino Acid Degradation, Problem Set IV Oct 28 Urea Cycle Oct 29 Principles of regulation of central metabolic pathways Oct 30 Problem Set III / Review (Koehler) Oct 31 Problem Set III / Review (Koehler) 6 Nov 3 Mechanisms of regulation Nov 4 Hormonal Regulation, Problem Set V Nov 5 Ammonia Assimilation Nov 6 Question and Answer/Review (Koehler) Nov 7 Question and Answer/Review (Koehler) 7 Nov 10 Nitrogen Fixation Nov 11 Holiday Nov 12 EXAM II (Material covered through Nov. 5) Nov 13 Free day (Review or test explanation can be scheduled) Nov 14 Free day (Review or test explanation can be scheduled)8 Nov 17 Amino Acid Biosynthesis, Problem set VI Nov 18 Biosynthesis of physiological amines Nov 19 Isoprenes Nov 20 Problem Set V, VI/ Review (Koehler) Nov 21 Problem Set V, VI/ Review (Koehler) 9 Nov 24 Sterol Metabolism Nov 25 Complex Lipids Nov 26 Regulation of Cholesterol Metabolism Nov 27 Thanksgiving 10 Dec 1 Photosynthesis—Dark Reactions, Problem set VII Dec 2 Photosynthesis—Calvin Cycle Dec 3 Photosynthesis—Light Reactions Dec 4 Question and Answer (Koehler) Dec 5 Question and Answer (Koehler) 11 Dec 10 FINAL EXAM (Cumulative) TEXT: “Lehninger Principles of Biochemistry”, 3rd Edition by Nelson and Cox (Worth). Specific reading will be announced each week. Check VOH if you miss announcements. Please review Chapters in the text in preparation for this class. These topics were covered in 153A (which is a pre-requisite for this class). Readings from Lehninger Principles of Biochemistry (Nelson and Cox, 3rd Edition) Week 1 • Review of biochemical concepts and central metabolic pathways, Problem Set I pp. 1-12; 485-508;527-540; 542, 544; 567-584 • Carbohydrate degradation—pp. 547-550 • Glycogen Synthesis—pp. 735-738; 742 Week 2 • Gluconeogenesis, Glyoxylate pathway—pp. 722-731; 588-590; 733-734 • Pentose phosphate pathway—pp. 545; 558-559 • Lipid degradation, Problem Set II—pp. 598-603 Week 3 • Fatty acid oxidation—pp. 604-609 • Ketone bodies—pp. 614-618 • Fatty acid biosynthesis, Problem Set III—pp. 585-586; 770-783 Week 4 • Deamination, transamination and cofactors—pp. 623-633; 640-642 • Amino acid degradation—pp. 639; 643-654Week 5 • Urea Cycle, Problem Set IV—pp. 634-638 • Principles of regulation of central metabolic pathways—pp. 278-289; 449-454; 551-554; 557; 590-591; 731; 738; 780; 869-874 Week 6 • Hormonal regulation, Problem Set V—pp. 874-878; 878-882; 449-454; 601 • Nitrogen fixation—pp. 818-822 Week 7 • Ammonia assimilation—pp. 823-826 • Amino acid biosynthesis, Problem Set VI—pp. 827-831; 832-833 Week 8 • Biosynthesis of physiological amines—pp. 844-845 • Isoprene pathway metabolism—pp. 813; 799-804 Week 9 • Sterol biosynthesis—pp. 804-812 • Complex lipids—pp. 788-796; 798 Week 10 • Principles of photosynthesis and Calvin Cycle, Problem Set VII—pp. 691-692; 746-755 • “Light” reactions—pp. 693-699; 703-710 • Regulation of photosynthesis—pp.


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UCLA CHEM 153C - Syllabus

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