Lecture/Day/Date Topic / Reading in textbookNo Paper this weekPaper #6Brock et al. (1999) Arachidonic acid is preferentiallymetabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J. Biol. Chem. 274, 11660-11666.Chem 153C Fall 2001 Lecture Schedule and Reading List (9/24/01) Fall 2001 Chemistry and Biochemistry 153C “Metabolism and Regulation” Dr. Catherine Clarke, Instructor Office 5072B Young Hall Tel: (310)825-0771 FAX: (310)206-5213 Email: [email protected] Lecture M,W,F 1:00-1:50 PM, Young CS24 Tutorial T 1:00-1:50 PM, Young CS50 Discussion Section / Research Paper Presentations / TA 1B Wednesday 9:00-9:50 AM, Boelter 5422 UyenPhuong Tran 1C Wednesday 12:00-12:50 PM, Boelter 5420 Suzie Ward 1D Thursday 9:00-9:50 AM, MS 3915D UyenPhuong Tran 1E Friday 11:00-11:50 AM, MS 3915D Diana Davis Teaching Assistants Email address Office Hours (1225 YH) Diana Davis [email protected] Wednesday 2- 3 PM UyenPhuong Tran [email protected] Friday 3- 4 PM Suzie Ward [email protected] Monday 2- 3 PM Cathy Clarke Tuesday 10-11 AM Required Textbook: David L. Nelson & Michael M. Cox Lehninger Principles of Biochemistry, Third Edition, Worth Publishers, 2000 Old exams are available via Virtual Office Hours (VOH). Grading: First midterm, 80 points; 2nd midterm 90 points, final 150 points. Research Paper presentation 40 points. Participation and written evaluations of student presentations 40 points. Research papers will be presented by groups of students in Discussion Section. The final exam must be taken in order to pass the class. Exam Policy: If the schedule of exams is not compatible with your schedule for this quarter, please do not enroll in this class. Makeup Exam Policy: Make-up exams will be provided for students who missed the regularly scheduled exam due to documented illness. An appropriate written note from your doctor must be given to Dr. Clarke before a make-up can be scheduled. The note must state the nature of the illness, its severity, and the duration of the disability and be signed by the physician. In cases of serious family emergencies, documentation must be presented to Dr. Clarke before a make-up exam can be scheduled. Make-up exams must be completed within 2 weeks of the class exam. Incomplete Policy: Incompletes are only given when fully documented serious illness or other emergency prevents a student who is otherwise passing the course from completing the course material. Note that this is an "impacted class" and students are not allowed to drop an impacted class after the second week of classes. Academic Honesty Policy: Any suspected problems involving academic honesty will be reported immediately to the Dean of Students Office.Chem 153C Fall 2001 Lecture Schedule and Reading List (9/24/01) Fall 2001 Chemistry and Biochemistry 153C "Metabolism and Regulation" Tentative Lecture Schedule and Textbook Reading List Lecture/Day/Date Topic / Reading in textbook T Sept. 25 Tutorial – Reading Scientific papers 1 W Sept. 26 Introduction – scope of the course Review 153A material, pp. 490-522 (Chapter 14); pp. 527-557 (Chapter 15); pp. 568-587 (Chapter 16); pp. 659-690 (Chapter 19) F Sept. 28 No meeting 2 M Oct. 1 Utilization of Fats as Energy Stores pp. 598-603 (Chapter 17) pp. 366-368 (Ch. 11); p. 880 (Ch. 23) 3 T Oct. 2 Beta oxidation of fatty acids pp. 604-608 (Chapter 17) pp. 503-505, 512-521 (Ch. 14) (FAD and NAD+) 4 W Oct. 3 Oxidation of unsaturated and odd chain fatty acids pp. 608-615 (Chapter 17) p. 585 (Ch 16) (Biotin and Cobalamin) 5 F Oct. 5 Ketone bodies pp. 615-618 (Ch 17) p. 880-881 (Ch. 23) Paper #1 McGarry, J.D. and Brown, N.F. (1997) The mitochondrial carnitine palmitoyltransferase system. Eur. J. Biochem. 244, 1-14. 6 M Oct. 8 Amino acid degradation/Transamination pp. 623-633 (Ch. 18) (pyridoxal-phosphate) T Oct. 9 Tutorial 7 W Oct. 10 Nitrogen Excretion and the Urea Cycle pp. 634-638 (Chapter 18) 8 F Oct. 12 THF as a one carbon carrier in amino acid degradation pp. 639-641 (Chapter 18) (THF) No Paper this week 9 M Oct. 15 Methionine metabolism pp. 640-643 (Chapter 18) Conversion of amino acids to Acetyl CoA pp. 643-645 (Chapter 18) T Oct. 16 Tutorial 10 W Oct. 17 Phe catabolism pp. 645-648 (Chapter 18) (Biopterins) F Oct. 19 FIRST MIDTERM EXAM (Covers through lecture 9) Paper #2 Chen et al. (2001)Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia.... Human Molecular Genetics 10, 433-443 http://hmg.oupjournals.org/cgi/reprint/10/5/433.pdf 11 M Oct. 22 Conversion of amino acids to Citric Acid Cycle Intermediates and Acetyl CoA pp. 643-645, 648-654 (Chapter 18) Gluconeogenesis pp. 722-730 (Ch. 20) T Oct. 23 Tutorial 12 W Oct. 24 Glyoxylate Cycle pp. 588-591 (Ch. 16) 13 F Oct. 26 Biosynthesis of Amino Acids – Nitrogen Fixation pp. 818-822 (Chapter 22) Paper #3 Waters et al. (2000) Characterization of phenylketonuria missense substitutions,... Mol. Genet. Metabol. 69, 101-110. 14 M Oct. 29 Getting Ammonia Into Amino Acids pp. 823-825 (Chapter 22) T Oct. 30 Tutorial 15 W Oct. 31 Nonessential amino acid biosynthesis pp. 826-829 (Chapter 22) 16 F Nov. 2 Essential Amino Acid Biosynthesis pp. 830-833 (Chapter 22) Synthesis of Amino Acid Byproducts pp. 840-842 (Chapter 22) Paper #4 Benov, L. and Fridovich, I. (1999) Why superoxide imposes an aromatic amino acid auxotrophy on Escherichia coli. J. Biol. Chem. 274, 4202-4206. http://www.jbc.org/cgi/reprint/274/7/4202.pdfChem 153C Fall 2001 Lecture Schedule and Reading List (9/24/01) 17 M Nov. 5 Synthesis of Amino Acid Byproducts pp. 844-848 (Chapter 22) T Nov. 6 Tutorial 18 W Nov. 7 Guest Lecturer: Dr. Jon Fukuto, Dept. Mol. Med. Pharm. Nitric Oxide Synthase 19 F Nov. 9 Start Lipid Biosynthesis – MalonylCoA pp. 770-776 (Chapter 21) Thursday & Friday discussions do paper #5 (see next week) M Nov. 12 VETERANS DAY HOLIDAY T Nov. 13 Tutorial W Nov. 14 SECOND MIDTERM EXAM (Covers through lecture 19) 20 F Nov. 16 Palmitic acid Biosynthesis and regulation pp. 776-780 (Chapter 21) Paper #5 Abu-Elheiga et al. (2001) Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science