GENE 412 1st Edition Lecture 8 Outline of Last Lecture I Calculating a path with multiple paths II X linked III The consequence of consanguinity Outline of Current Lecture I What does inbreeding do II How inbreeding relates to evolution III Difference between F f IV Examples Current Lecture I II What does inbreeding do a Genotypic level changes genotype so dramatically but does it change allelic frequency How inbreeding relates to evolution a Inbreeding is not an evolutionary force i Doesn t change ALLELE frequency ii p 6 q 4 iii Inbreed population completely means to distribute alleles to homozygotes 1 Does not affect variation of alleles in population iv p 6 q 4 1 P1 AA Aa aa 36 48 16 F1 AA Aa aa 6 0 4 b f correlation of uniting gamation i 1 f 1 ii f HeterozygotesExp for H W Observed Heterozygotes HeterozygotesExp for H W These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute III Differences in F inbreeding coefficient and f inbreeding coefficient F f IV Specific Individual Probability of homozygosity 0 F 1 Identity by descent pedigree Local population Correlation coefficient 1 f 1 System of mating Defined by deviation from expected H W genotype frequencies Examples a 1969 1972 i observed Heterozygotes Hets in a small inbred population of gazelles 1 obs Hets 5 2 Expected Hets 375 3 375 5 375 1 3 4 The reason f is negative with such an inbred population is the breeders were intentionally trying to mate least related individuals 5 Bottom line Picking a mate in a population that is the least related to you will give you a negative f value