GENE 412 1st Edition Lecture 6 Outline of Last Lecture I How D Changes over time II Example of D Recombination Problem Outline of Current Lecture I Recombination Frequency II Introduction to Inbreeding Current Lecture I II Recombination Frequency a AB ab Only class that can produce Ab b Is aa good marker for b c From previous lecture D3 1 6 i This value shows that a is NOT a good marker for b because 1 6 is too small ii For it to be a good marker D would be a lot closer to 1 iii Perfect marker D equals exactly 1 d Test Cross data A B Parental A b Recombinant a B Recombinant a b Parental Introduction to Inbreeding a F inbreeding coefficient i Produced by Malecot b Inbreeding Probability of homozygosisty by descent of an allele from a common ancestor c F P aa by descent selfing sibling mating 1 8 half sibling uncle niece 1 16 cousin d Make sure to go over basic Pedigree rules e F A1A2 i P A1A1 or P A2A2 or P A1A2 or P A2A1 These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute ii 1 2 1 2 1 2 1 2 1 2 FA 1 2 1 FA 1 2 1 1 2 3 4