11 5 13 Daltons Law Patom PN2 PO2 Pco2 carbonic anhydrase CO2 H2O H2CO3 oxyhemoglobin 11 05 2013 H HCO3 Factors that influence hemoglobin affinity for O2 In PO2 increase af decrease H decrease PCO2 inc affinity decrease temp increase affin decrease DPG lots of oxygen inc affinity less oxygen more affinity In tissue all of these examkples decrease affinity need oxygen to come of in tissue so need that decrease in affinity decrease PO2 increase PCO2 H decrease pH increase temp increase DPG Oxygen hemoglobin dissociation curve shift to the right decrease affinity is this good or bad depends on where im at if i had this shift to the right in the lungs thats bad in the tissue its good o inc dpg o inc temp o decrease pH shift for pH borr shift shift for temperature shift for DPG CO2 transport Dissolved in plasma 10 small but significant bound to hemoglobin 30 somewhere between the other 2 bicarbinate 60 most chloride shift 11 05 2013 11 05 2013