Murein Biosynthesis TutorialSlide 2Formation of Amino SugarsSlide 4Slide 5Murein Biosynthesis TutorialWillie Claiborne Brown, Ph.D.Professor EmeritusUniversity of California, San DiegoJanuary, 2001byNAGNAMUridine Diphosphate-N-Acetyl GlucosamineUridine Diphosphate-N-Acetylmuramic AcidL-AlanineD-Glutamic AcidDibasic Amino AcidD-AlanineTri-Alanine PeptideBactoprenol Carrier Lipid-Derivative of a C-55 Polyisoprenoid AlcoholD-AlanineFormation of Amino SugarsFructose-6-PAcetyl CoAGlutamine(NH2)UTPPOther Other Cell Cell ReactionsReactionsPhosphoenol Pyruvate(Lactyl)N-Acetylglucosamine(NAG)Reduction StepsNAMNAGSequence of Events inMurein BiosynthesisPNAMBactoprenolUMPNAG[Alanine Branch]NAGNAG NAMNAMNAMNAGNAGNAGNAGBactoprenolNAMNAGNAGBactoprenolNAMNAGNAGNAMNAGNAGPBactoprenol P-P12-4567891011121314ATPATPATPATPATPNAMPBactoprenolP[Crosslinking Step]Sequence of Events inMurein BiosynthesisPNAMUMPNAG[Alanine Branch]BactoprenolNAMNAGNAGBactoprenolNAMNAGNAGBactoprenolPBactoprenol P-P12-4567891011121314ATPATPATPATPATPNAMPBactoprenolPNAGNAG NAMNAMNAMNAGNAGNAGNAG NAMNAGNAG[Crosslinking
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