BIMM 124 FINAL Professors Brown and Aroian Spring, 2006 Multiple Choice (5 points) 1. Which of the following are beneficial uses of fungi? I. vaccines II. steroids III. fermentation IV. organic acids V. recycles nutrients in the soil a) II, III, V b) I, II, IV c) II, III, IV, V d) II, III, V e) All of the above 2. Your friend is only applying to medical school, yet he already believes people should listen to his advice as if he were already a doctor. He is listing the reasons you should be vaccinated with an attenuated vaccine rather than an inactivated vaccine, but you, the microbiologist, realize he made an error. Which of his statements is incorrect? a) attenuated vaccines are much more stable at warm temperatures. b) generally you only need a single dose of an attenuated vaccine. c) attenuated vaccines provide long term protection. d) attenuated vaccines provoke a good cellular immune response. e) attenuated vaccines can cause both an IgG and IgA response. 3. Which of the following are TRUE about superficial mycoses? a) colonize living tissues b) illicit strong cellular response c) cause no physical response d) jock itch is a superficial mycosis e) difficult to treat 4. In Microbiology lab, your instructor asks you identify an unknown bacterium. The sample appears to have very slow growth, is difficult to stain and is very resistant to chemicals. What is the possible identity of your bacterium? a) Staphylococcus b) Listeria c) Diphtheriae d) Mycobacterium e) StreptococcusBIMM 124 Final,SP06, Page 2 5. Which of the following characterizes a fungal hypersensitivity disease? I. spores act as an antigenic stimulus II. growth of fungi is required III. treated with amphotericin B IV. clinical manifestations include bronchial asthma a) I only b) I, II, IV c) I, IV d) II, IV e) all of the above 6. Which of the following is the role of a polyglutamyl capsule? a) binds to receptors on cell membranes b) forms a pore inside the cell vesicle c) promotes endocytosis into the host cell d) simulates adenylate cyclase activity e) protects the bacterium from phagocytosis 7. Which of the following episodes provided us with much of the epidemiologic and pathologic details of inhalation anthrax that we currently have? a) during World War I a sugar cube containing anthrax b) Gruinard Island studies c) Sverdlovsk incident in USSR d) bioterrorist attack of 2001 e) Pasteur’s groundbreaking work 8. As a fungus, you want to infect the next person to touch this piece of paper. Unfortunately, you realize the skin is an excellent primary barrier to infection. All of the following are reasons this is true EXCEPT: a) bacteria of the normal skin flora out compete fungi for nutrients b) high pH c) skin sheds at a high rate d) the skin’s fatty acid content e) all of the above are trueBIMM 124 Final,SP06, Page 3 For numbers 9 through 11, match the correct characteristic with the following anti-fungal drugs (each can be used more than once) a) amphotericin B b) 5-flucytosine c) clotrimazole d) relenza e) lamisil 9. This drug inhibits squalene epoxidase. 10. This drug is primarily used in life threatening situations. 11. This drug rapidly induces resistance in susceptible organisms. 12. How many of the following statements about inhalation anthrax are TRUE? I. The typical incubation period is 1 month II. Macrophages are responsible for the spread of spores from the lungs III. Initial symptoms are similar to an allergic response IV. During the bioterrorist attacks of 2001, the death rate was 45% V. Mediastinal narrowing occurs in many cases a) One b) Two c) Three d) Four e) Five 13. To celebrate another successful quarter at UCSD, you decide to organize your BIMM124 notes into a scrapbook so that you will always remember the fun you had. When you get to the section covering cutaneous anthrax infections, which of the following will you NOT see? a) even without treatment most cases are not fatal b) the first symptom is an insect-like bite c) a vesicle at the site of infection can become hemorrhagic d) a papule is a black scab found on the infected area e) all of the above statements should be in your notes 14. Which of the following does NOT characterize Histoplasmosis? a) it is a systemic mycosis b) less than 1% becomes progressive and requires therapy c) present in the Ohio and Mississippi valleys d) found only in yeast form e) infection leads to long term immunityBIMM 124 Final,SP06, Page 4 For questions 15-17, match the following characteristics with the correct Bacillus anthracis protein. Each can be used more than once. a) protective antigen monomer b) lethal factor c) edema factor d) polyglutamyl capsule e) protective antigen heptamer 15. This protein turns ATP into cyclic AMP. 16. This protein is responsible for cleavage of the MAP kinase protein. 17. This protein forms a pore in the host endosome. 18. Which of the following is NOT a part of the Molecular Postulate for Disease? a) virulence genes must be expressed in disease b) presence of the organism always presents a disease c) antibodies must be protective against the virulence factor d) genetic virulence must be expressed in every pathogenic strain e) none of the above 19. As a young bacterium, you are going to college in order to learn how to spread disease. Which of the following will you not learn in Establishment of Infection 101? a) bacterial invasion precedes bacterial colonization b) a pathogen must adhere to the host in order to establish an infection c) invasion does not need to occur to cause an infection d) there are three major causes of damage that can occur following subversion of the host defenses e) all of these are true 20. Which of the following is NOT a main goal of the bacterium when causing infection? a) avoiding host immune defenses b) entering the host through a susceptible point of entry c) obtaining iron for growth d) taking over host cell machinery e) none of the above 21. Biofilms are NOT responsible for which of the following diseases? a) pneumonia b) cystic fibrosis c) dental caries d) musculoskeletal disease e) all can be a result of biofilmsBIMM 124 Final,SP06, Page 5 22. Dr. Brown comes in complaining of constant vomiting and diarrhea within the past three hours of eating warm coleslaw from KFC. You have determined that he probably has food