Slide 1Formation of Amino SugarsSlide 3Inhibition of NAM FormationWCBSlide 6Slide 7Inhibition of Murein Biosynthesis TutorialWillie Claiborne Brown, Ph.D.Professor EmeritusUniversity of California, San DiegoJanuary, 2001byWCBWCBFormation of Amino SugarsFructose-6-PAcetyl CoAGlutamine(NH2)UTPPOther Other Cell Cell ReactionsReactionsPhosphoenol Pyruvate(Lactyl)N-AcetylglucosamineReduction StepsNAMNAG(NAG)Sequence of Events in Murein BiosynthesisPNAMUMPNAG[Alanine Branch]BactoprenolNAMNAGNAGBactoprenolNAMNAGNAGBactoprenolPBactoprenol P-P12-4567891011121314ATPATPATPATPATPNAMPBactoprenolPNAGNAG NAMNAMNAMNAGNAGNAGNAG NAMNAGNAG[Crosslinking Step]Inhibition of NAM FormationFructose-6-PAcetyl CoAGlutamine(NH2)UTPPOther Other Cell Cell ReactionsReactionsPhosphoenol Pyruvate(Lactyl)N-AcetylglucosamineReduction StepsNAGFosfomycin(NAG)Effect of D-Cycloserine on Murein BiosynthesisNAM[Alanine Branch]12-457891011121314ATPATPATPNAGNAG NAMNAMNAMNAGNAGNAGNAG[Crosslinking Step]WCBWCBEffect of Bacitracin on Murein BiosynthesisNAMUMPNAG[Alanine Branch]BactoprenolNAMNAGNAGBactoprenolNAMNAGNAGBactoprenolPBactoprenol P-P12-4567891011121314ATPATPATPATPATPNAMPBactoprenolPNAGNAG NAMNAMNAMNAGNAGNAGNAG NAMNAGNAG[Crosslinking Step]WCBWCBEffect of Beta Lactam Antibiotics onMurein BiosynthesisPNAMUMPNAG[Alanine Branch]BactoprenolNAMNAGNAGBactoprenolNAMNAGNAGBactoprenolPBactoprenol P-P12-4567891011121314ATPATPATPATPATPNAMPBactoprenolPNAGNAG NAMNAMNAMNAGNAGNAGNAG NAMNAGNAG[Crosslinking
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