Nester, E.W., et al. Microbiology: A Human Perspective, 3rd Edition, New York, 2002.Nester, E.W., et al. Microbiology: A Human Perspective, 3rd Edition, New York, 2002.Risk Factors for Pneumonia ∗ Age--highest in people under two or over 60 ∗ Acute and Chronic Ailments Ø Influenza--viruses damage ciliated epithelial cells Ø Bronchitis/Emphysema/Asthma/Lung cancer--abnormal mucus; protects from phagocytosis Ø Heart Failure--abnormal circulation--impairs host defense Ø Immune Suppression--AIDS, etc ∗ Environmental Irritants--smoking; air pollution--destroy ciliated epithelial cells ∗ Alcholic Intoxication Depresses Cough Reflex Depreses Phagocytic responseHIGH BLOOD TITER • Sialic Acid Capsule • Perceived as self • Escape host defenses CAPACITY TO INVADE • Self-directed invasion • GBS macromolecular synthesis • Host cytoskeletal involvement Signature Events in Development of Meniningitis by GBS DAMAGE TO BBB 1- Damage by GBS ß-h/c 2- Damage by Host Inflammation TRANSCYTOSIS GBS crosses BBB to reach
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