Bauman, R. W., Microbiology, Pearson, New York, 2004, p.549.Perry, Jerome J., James T. Staley, and Stephen Lory. Microbial Life, Sinaeur Associates, Sunderland MA, ISBN 0-87893-675-0Comparison and Contrast of Tetanus and Botulinum Toxins Property Botulinum toxin Tetanus toxin Location in bacterium Bacteriophage Plasmid Molecular structure A-B A-B Class of macromolecule Zinc endopeptidase Zinc endopeptidase Serological types Seven (A-G) One Potency* High High Clinical symptoms Flaccid paralysis Spastic paralysis Site of Action Neuromuscular Junction Central Nervous System (Inhibitory interneurons) Function Block release of neurotransmitters from peripheral neurons, e.g. Acetycholine Block release of transmitters from inhibitory interneurons Mechanism Cleavage of synaptobrevins Cleavage of
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