Glycolysis Steps and Regulation - Flashcards
17 Cards in this Set
| Front | Back |
|---|---|
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Hexokinase -location -what rxn -cofactors?
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in most tissues
glucose --> glucose-6-phosphate
ADP -->ATP
Mg2+
IRREVERSIBLE
|
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phosphoglucoisomerase (PGI) -rxn -cofactors?
|
G6P-->Fructose-6-phosphate
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Glucokinase -location -rxn -cofactors
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LIVER
Glu-->G6P
ADP-->ATP
IRREVERSIBLE
|
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PFK1 -rxn -cofactors
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F6P-->F1,6BP
ADP-->ATP
Mg2+
|
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Aldolase -rxn
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F1,6BP -->DHAP + GA3P
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GA3P DH + TIM -rxn -cofactors
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DHAP + GA3P --> 1,3BPG
NAD+-->NADH
|
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PGK -rxn -cofactors
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1,3BPG ---> 3PG
ADP-->ADP
Mg2+
|
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PGM -rxn -cofactors
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3PG --> 2PG
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Enolase -rxn -cofactors
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2PG --> PEP
H20 created
|
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Pyruvate Kinase -rxn -cofactors
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PEP --> Pyruvate
ADP--> ATP
IRREVERSIBLE
|
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What inhibits Hexokinase
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G6P
Direct Feedback Inhibition
|
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What inhibits Glucokinase
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F6P
Indirect Feedback Inhibition
**F6P inhibition blocked by F1P
|
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What enzyme makes F6P --> F2,6BP
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PFK2
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What inhibits PFK1
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ATP (this inhibition blocked by AMP)
Citrate
|
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What activates PFK1
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F2,6BP
|
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What inhibits Pyruvate Kinase
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ATP
Alanine
Acetyl-CoA
Hormones (in liver)
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What activates Pyruvate Kinase
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AMP
F1,6BP
Insulin (in liver)
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Gluconeogenesis - Flashcards