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Glycolysis Steps and Regulation - Flashcards
Hexokinase -location -what rxn -cofactors? |
in most tissues
glucose --> glucose-6-phosphate
ADP -->ATP
Mg2+
IRREVERSIBLE |
phosphoglucoisomerase (PGI) -rxn -cofactors? |
G6P-->Fructose-6-phosphate |
Glucokinase -location -rxn -cofactors |
LIVER
Glu-->G6P
ADP-->ATP
IRREVERSIBLE |
PFK1 -rxn -cofactors |
F6P-->F1,6BP
ADP-->ATP
Mg2+ |
Aldolase -rxn |
F1,6BP -->DHAP + GA3P |
GA3P DH + TIM -rxn -cofactors |
DHAP + GA3P --> 1,3BPG
NAD+-->NADH |
PGK -rxn -cofactors |
1,3BPG ---> 3PG
ADP-->ADP
Mg2+ |
PGM -rxn -cofactors |
3PG --> 2PG |
Enolase -rxn -cofactors |
2PG --> PEP
H20 created |
Pyruvate Kinase -rxn -cofactors |
PEP --> Pyruvate
ADP--> ATP
IRREVERSIBLE |
What inhibits Hexokinase |
G6P
Direct Feedback Inhibition |
What inhibits Glucokinase |
F6P
Indirect Feedback Inhibition
**F6P inhibition blocked by F1P |
What enzyme makes F6P --> F2,6BP |
PFK2 |
What inhibits PFK1 |
ATP (this inhibition blocked by AMP)
Citrate |
What activates PFK1 |
F2,6BP |
What inhibits Pyruvate Kinase |
ATP
Alanine
Acetyl-CoA
Hormones (in liver) |
What activates Pyruvate Kinase |
AMP
F1,6BP
Insulin (in liver) |