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What are the three functions of respiration?
Ventilation, gas exchange, and oxygen utilization.
What is ventilation?
The external mechanism of breathing. Drawing air in and out of lungs for gas exchange. BREATHING.
What is gas exchange?
Takes place between the air and blood in the lungs between body tissues and blood.
Takes place between the air and blood in the lungs between body tissues and blood.
Diffusion. Oxygen moves from higher concentrations to lower concentrations.
What is the diaphragm?
The most important muscle for breathing.
Is breathing voluntary or involuntary?
Both
What is the conducting zone?
Conducts air into the respiratory zone. Consists of nose, pharynx, lugs, trachea, bronchi.
What is the respiratory zone?
The site of gas exchange. Consists of terminal bronchioles, respiratory bronchioles and ALVEOLI.
Where does gas exchange take place?
Alveoli (in the respiratory zone)
What are alveoli sacs made of?
Alveoles. 300 million total.
What makes alveoli idea for gas exchange?
Large surface area, short diffusion distance, density of capillaries.
How many cell layers are alveoli made of?
1- simple squamous.
How many layers are in between alveoli and gas?
2. The alveoli epithelial layer and the endothelial layer of the capillary.
What are the physical aspects of ventilation?
What are the physical aspects of ventilation?
When the pressure in the lungs is ____ than the pressure in the air, inhalation occurs.
higher
When the pressure in the lungs is _____ than the pressure in the air, expiration occurs.
lower
What three things allow us to easily inhale and exhale?
Compliance, elasticity, surface tension in the lungs.
What is compliance?
How easily lungs expand with pressure when we inhale.
What affects compliance?
Elasticity and surface tension
What is elasticity?
The presence of high amounts of elastin proteins causing the lungs to contract quickly. Tendency to return to initial size after distension.
What is surface tension?
H2O molecules attracting to one another via hydrogen bonds. Potentially making alveolar sacs collapse.
What causes surface tension?
The lungs secreting and absorbing fluid, leaving a thin film on the alveolar surface.
Pressure of alveoli is equal to _____ ______.
Surface tension.
What does a surfactant do?
Resist surface tension by getting in between water molecules and reducing their ability to contract.
Who gets respiratory distress syndrome and why?
Infants because the body hasn't made any sufactant.
What are the two phases of pulmonary ventilation?
Inspiration (inhaling) and expiration (exhaling).
What is breathing based on?
Pressure inside lungs and atmosphere.
What controls quiet breathing?
The contraction of the diaphragm and the relaxation of the diaphragm.
What controls deep breathing?
Mostly chest muscles.
Pulmonary ventilation is a _____ process.
Mechanical
What is intrapulmonary pressure?
Pressure inside the lungs/alveoli
What is intrapleural pressure?
Pressure inside the pleura around the lungs.
What is transpulmonary pressure?
The difference between intrapulmonary and intrapleural pressures.
What is atmospheric pressure?
Pressure of the atmosphere.
Intrapleural pressure is always ____ than intrapulmonary pressure.
less
What happens during inspiration?
What happens during inspiration?
Quiet breathing is a _____ process and deep breathing is a ______ process.
passive, active
What is deep breathing caused by?
Contraction of abdominal muscles.
What controls respiration?
What controls respiration?
What does the medulla control?
What does the medulla control?
What does the pons do?
Influence the rhythmicity center in the medulla.
What do inspiratory and expiratory neurons do?
Drive inspiration and expiration.
Where is the apneustic center and what does it do?
In the pons. It stimulates inspiratory neurons.
Where is the pneumotaxic center located and what does it do?
The pons. It Antagonizes the apneustic center which inhibits inspiration.
Where are the central chemoreceptors monitoring O2, CO2 and pH?
In the medulla.
Where are peripheral chemoreceptors located?
In the heart and carotids.
What is a pulmonary function test?
A test measuring the air inhaled and exhaled assessed by spirometry.
What is tidal volume?
Volume of air inhaled and exhaled during normal breathing.
What is vital capacity?
Total volume of air able to be forcefully inhaled and exhaled.
What is residual volume?
Volume left in the lungs after max exhalation.
What is total lung capacity?
Total amount of air you can hold.
Total amount of air you can hold.
Measure of a gas in a mixture by itself.
What is total pressure of a gas mixture?
partial pressure x all gasses present.
What happens when blood and alveolar air are at equilibrium?
Oxygen in blood reaches max volume.
What does equilibrium of blood and alveolar air depend on?
What does equilibrium of blood and alveolar air depend on?
Arteries have more ___ than ___. Veins have more ____ than ____.
02 than CO2. CO2 than O2.
What does hemoglobin do?
Picks releases 02 and picks up CO2 in the tissues and picks up O2 and releases CO2 in the lungs.
What changes hemoglobin affinity for O2 and CO2?
Concentration of 02 and CO2.
What is anemia?
Hemoglobin levels are low in the blood.
What is hemoglobin production controlled by?
Erythropoietin
What are characteristics of hemoglobin?
It's a protein with 4 subunits each with a heme that binds to 1 O2.
What is made when O2 binds to hemoglobin?
Oxyhemoglobin.

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