Front Back
neuraxis
imaginary line drawn though the spinal cord up to the front of the brain
rostral
toward the head (anterior)
caudal
toward the tail (posterior)
ventral
toward the belly (inferior)
dorsal
toward the back or top of the head (superior)
medial
toward the middle
ipsilateral
same side of the brain
contralateral
opposite side of the brain
3 planes of the brain
sagittal- through the mid-sagittal plane coronal (transverse)- vertical cut through the brain horizontal- horizontal cut through the brain
Three types of primordial tissue
endoderm mesoderm ectoderm
which of the 3 primordial layers does the nervous system develop from?
ectoderm
how does the neural tube form and what does it become?
tissue folds in upon itself becomes the CNS
Three-vesicle stage
forebrain midbrain hindbrain
five-vesical stage
forebrain-> telencephalon and diencephlon midbrain- mesencephalon hindbrain-> metencephalon and myelincephalon
neurogenesis
process by which new neurons and glia are produced from stem cells in the inside of the neural tube
central nervous system
comprised of brain and spinal cord
spinal cord
conduit for information to and from the brain
peripheral nervous system comprised of:
-cranial/spinal nerves and peripheral ganglia (somatic NS) -autonomic nervous syste
autonomic nervous system
controls smooth and cardiac mucles and glands
Efferent nerves
PNS nerves that project to target organs and to muscles
Afferent nerves
PNS nerves that carry sensory information to the brain
meninges
series of membranes which are located above the brain but below the skull
3 types of meninges
Dura matter- outer (thick) layer Arachnoid-middle layer, overlies the arachnoid space (CSF), blood vessels run throughout arachnoid layer Pia matter- inner layer, overlies every detail of the brain
Cerebrospinal fluid (CSF)
-comprises extracellular space of brain, spinal cord and the four brain ventricles produced by choroid plexus of each ventricle continuous circulaion
Brainstem
divides the brain into midbrain, and hindbrain
Telencephalon
part of the forbrain containss the cerebral cortex, basal ganglia, and limbic system
Three parts of the telencephalon
cerbral cortex, basal ganglia, lymbic system
describe the cerebral cortex
-part of the telecephalon -outer surface of the cerebral hemisphere -comprised of grooves (sulci and fissures) and bulges (gyri) -composed primarily of cells so grey appearance -2-6mm thick (formed from 6 layers of cells)
what is the name for small and large grooves in the cerebral cortex?
small grooves- sulcus large grooves- fissure
name for bulges in the cortex?
gyrus (gyri-plural)
What are the 4 lobes of the Cerebral cortex?
Frontal, parietal, occipital, temporal
Describe location and function of frontal lobe
-anterior portion of cortex, rostral to parietal lobe, dorsal to temporal lobe -controls movements of skeletal muscle (connections are contralateral)
what is the central sulcus
divides frontal and parietal lobe
where is the primary motor cortex located
anterior to central sulcus in frontal lobe
describe location and function of parietal lobe
-in between frontal and occipital lobe, superior to temporal lobe -contains somatosensory cortex
where is the somatosensory cortex located?
just posterior to the central sulcus
describe location and function of occipital lobe
posterior portion of cortex contains primary visual cortex
describe location and function of temporal lobe
most inferior portion of cortex, anterior to occipital lobe contains primary auditory cortex in superior region
what are primary cortices?
receive info from specific sensory organs or directly control movements make up a small portion of the cortex
describe location and function of motor association cortex
region of the frontal lobe rostral to the motor association cortex involved in formulating plans and strategies; controls overall motor behavior
corpus callosum
bundle of axons that interconnects corresponding regions of the cerebral cortex severed in split-brain procedure
describe neocortex
phyocentically newest cortex contains primary sensory, motor and association cortecies
describe lymbic cortex
phylogenetically oldest cortex located at the medial edge of cerebral hemispheres (part of lymbic system)
What makes up the limbic system?
hippocampus, amygdala, mammillary bodies
what is the function of the hippocampus, amygdala, and mammillary bodies?
hippocampus- involved in learning and memory amygdala- involved in emotional response mammillary bodies-connected to hippocampus through Fornix (fiber bundle)
what is the cingulate gyrus?
strip of limbic cortex lying along the lateral walls of the groove separating the cerebral hemispheres, superior to the corpus callosum
What is the Basal Ganglia
part of the forebrain collection of subcortical nuclei that lie just adjacent to the anterior portion of the lateral venticals
What 3 areas make up the basal ganglia?
globus pallidua, caudate nucleus, putamen
what is the function of the basal ganglia?
involved in control of movvement input from motor regions of cerebral cortex and output to thalamic nuclei NO DIRECT input or motor output
Which disease results from damage to the basal ganglia?
Parkinson's Disease
which two areas make up the diencephalon?
Thalamus and hypothalamus
What is the function of the thalamus?
contains nuclei that receive sensory info and transmit it to the cortex sensory and motor integration
What 4 nuclei make up the thalamus and what are their functions?
Lateral geniculate nucleus- receives fibers from retina and projects to primary visual cortex medial geniculate nucleus- receives fibers from auditory system and projects to primary auditory cortex Ventroposterior (VPL)- receives input from somatosensory system ventrolateral- receives …
what is the function of the hypothalamus?
involved in integration of species-typical behaviors controls autonomic nervous system and pituitary glands controls the 4 F's (fighting, feeding, fleeing, mating), drinking, sleeping, and body temperature
what is a neurosecretory cell?
cell that secretes a hormone or hormone-like substance
What is the the posterior pituitary?
endocrine gland (neural tissue) containing hormone-secreting terminal buttons that are connected to the brain through axons
How is the anterior pituitary connected to the brain and what is its function?
connected through capillary beds controls reproduction and adrenal gland
What 2 areas make up the midbrain or mesencepalon?
tectum tegmentum
where is the tectum located?
dorsal part of the midbrain
where is the tegmentum located?
under the tectum
What makes up the tectum and what is their function?
Superior and inferior colliculi (4 bumps) involved in visual and auditory systems 2 superior = visual 2 inferior = audiorty
what areas make up the tegmentum?
rostral end of reticular formation periaqueductal gray red nucleus (motor regulation) substantia nigra (contains melanin, related to motor system) ventral tegmental area (contains dopaminergic cells)
Which 2 areas make up the hindbrain?
metencephalon myelencephalon
which 5 areas make up the metencephalon?
pons, cerebellum, cerebellar cortex, deep cerebral nuclei, cerebellar peduncles
what is the function of the pons?
a "bridge" that contains reticular formtion involved in the control of sleep and arousal
what is the function of the cerebellum?
involved in motor control receives visual, auditory, vestibular, and somatosensory information along with info about individual muscle movements being directed by the brain integrates the information and modifies the motor outflow, having a coordinating and smoothing effect on the movem…
what is the result of damage to the cerebellum?
jerkey, poorly coordinated movements
What makes up the myelencephalon?
medulla oblongata
what is the location and function of the medulla?
most caudal portion of the brain, rostral to the spinal cord contains part of the reticular formation nuclei control vital functions such as regulation of cardiovascular system, breathing, and skeletal muscle tone
Describe the spinal cord
protected by vertebral column made of 24 vertebrae spinal cord passes through the spinal foramen (openings) in each vertebrae
Describe the function of the spinal cord
distributes motor fibers to effector organs of the body and to collect somatosensory info to be passed to the brain certain degree of autonomy from the brain; various reflexive control circuits located here
what is the cauda equina?
bundle of spinal roots located caudal to the end of the spinal cord
what is a caudal block?
anesthesia and paralysis of lower part of the body by injection of local anesthetic into CSF surrounding the cauda equina
Afferent axon
directed toward CNS from muscles
Efferent axon
directed away from CNS to muscles
what are the two divisions of the peripheral nervous system?
somatic and autonomic
Describe the somatic nervous system?
comprised of nerves controlling muscle action and carry sensory information back to CNS 12 cranial nerves 31 spinal nerves
describe the autonomic nervous system?
governs smooth muscle, cardiac muscle and gland secretion
describe the parasympathetic division of the autonomic PNS
supports activities that will increase energy (ex. rest, digestion)
describe the sympathetic division of the autonomic PNS
supports arousal and the expenditure of energy (flight or flight)
what is a nerve
collection of axons outside the CNS
what is a tract
collection of axons inside the CNS
What is a nucleus
a collection of cell bodies inside the CNS
what is a ganglion
collection of cell bodies outside the CNS (except the basal ganglia inside the CNS)
Brocas Area
left hemisphere involved in speech production

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