Required texts:Classroom conductCOURSE OUTLINECourse Number:BIO208Credits: 4Course Title:GENETICSHours: 3 lecture/3 laboratoryRequired texts:iGenetics: A Molecular Approach, 2nd ed.Peter J. RussellBenjamin Cummings PublishersCourse Coordinator: L. BlindermanOffice: MS 110Phone: [email protected]/~blinderlCatalogue Description:A survey course examining gene activity at the molecular and organismal levels.Principles of transmission, molecular, and population genetics are covered withemphases placed on advances in genetic technology and applications. The laboratoryexercises address topics in heredity, chromosome structure, recombinant DNA,bioinformatics, and other molecular biology techniques. Three hours of lecture and onethree hour laboratory per week.Prerequisites: Successful completion of BIO 102 (C grade or higher) or consent of instructorGradingLecture: The lecture grade is based on examination grades, in-class activities, and homework assignments. The instructor must be informed within 12 hours of a missed exam. Makeup exams, given only for a valid and documented absence, are discouraged, and consist of essay questions.Laboratory: The laboratory grade is based on pre-labs, the laboratory notebook, attendance, and participation. The instructor will evaluate student performance throughout the semester. More than one unexcused absence will result in a lower lab grade. There are no makeup laboratories.Lab exams 15%Lab notebook (includes pre-labs and lab homework)20%Lecture exams 55%Lecture homework , worksheets, presentation 10%Classroom conductThe college welcomes students into an environment that creates a sense of community pride and respect. AttendanceIt is a student’s responsibility to attend all of his/her classes. If a class meeting is missed, the student is responsible for content covered, announcements made in his/herabsence, and for acquiring any materials distributed in class. More than 3 missed lectures may result in a lower grade for the course. The laboratory component of the course is critical to satisfying the course objectives. A student who misses more than two unexcused laboratory sessions will fail the course. A passing grade must be obtained in the laboratory in order to pass the course.TardinessIt is expected that students will be on time for all classes. Students late for an exam may be denied the opportunity to take the exam. A student who enters the laboratory late may not be able to participate in the lab. BehaviorStudents are expected to follow ordinary rules of courtesy during class sessions. The instructor has the right to eject a disruptive student from the class at any time. Cell phones and other devices are to be turned off prior to the start of class so that they are not used during class time. Accommodations2Any student in this class who has special needs because of a disability is entitled to receive accommodations. Eligible students at Mercer County Community College are assured services under the Americans with Disabilities Act and Section 504 of the Rehabilitation Act of 1973. If you believe you are eligible for services, please contact Arlene Stinson, the Director of Academic Support Services. Ms. Stinson’s office is LB221, and she can be reached at (609) 570-3525.Academic Integrity Statement: Cheating of any kind is not tolerated. Cheating includes copying papers or website information, presenting another person's work as one's own in any way, looking at a student's paper during a test or quiz, looking at notes during an exam or quiz, obtaininginformation about an exam, quiz, or any other information that other students do not have and the instructor does not intend them to have, or talking during an exam or quiz.Write your own papers using your own words. All violations of academic integrity will bereported to the Academic Integrity Committee. For additional information: Refer to the MCCC Student Handbook. Schedule of Lecture TopicsWEEK TOPIC CHAPTERSI Introduction and DNA Structure 1, 2II Transcription and Translation 5III Gene Expression 6IV (continued)EXAM 1V Mendelian Genetics and Extensions of Mendel 11, 13, 4VI Chromosomal Basis of Inheritance and Gene Linkage12VII Chromosome Variations 17EXAM 2VIII Bacterial Genetics 18X (continued) 19XI Recombinant DNA Technology 8XII (continued)EXAM 3XIII DNA mutation, Repair, Transposable Elements 7XIV Applications of Recombinant DNA Technology 9XV Population and Evolutionary Genetics 13EXAM 4Laboratory ScheduleLab Topic1 Lab notebook, Bioinformatics (computer lab)2 Isolation of DNA from animal and plant tissue33 Human DNA fingerprinting via the polymerase chain reaction (PCR)4 Electrophoresis, UV spectrophotometry5 LP#16 Mendelian Genetics, Chi Square, Probability, Pedigree analysis7 Cytogenetics, Karyotyping (computer lab)8 Restriction enzyme mapping 9 DNA mapping/ electrophoresis (continued)10 LP #211 Translation of mRNA (computer lab)12 Gene Expression: Transformation of bacteria with pGLO recombinant plasmid13 Transformation analysis14 Human evolutionary and population genetics (computer lab)*The Laboratory Schedule may be revised LABORATORY SAFETYYour instructor will call attention to safety precautions. FOOD AND DRINKS ARE NOT ALLOWED IN THE LABORATORY, ever!For working with chemicals:1. Wear gloves and safety goggles2. In the event of a spill, notify your instructor immediately3. Wash your hands with soap and water4. Wipe down your lab bench with disinfectant before and after use5. Read labels and follow instructions carefully6. Never use mouth suction in filling pipettes with chemical reagents. Use a suction bulb. Note the location of:1. the eye-wash station, fume hood, fire blanket, fire extinguisher, and safety goggles 2. the master shut-off switch for electricity 3. the unobstructed exitsBefore leaving, make certain that:1. all equipment is turned off 2. the chair is pushed in3. all work surfaces and equipment in the chemical or biological laboratory are thoroughly cleaned and left in a neat conditionTHE COURSE INSTRUCTOR RESERVES THE RIGHT TO CHANGE THE SCHEDULE AND GRADINGPROCEDURE AT ANY TIMECourse Competencies/Goals1. Elucidate the structure and packaging of DNA 2. Analyze the architecture of eukaryotic and prokaryotic genes and describe the regulation of gene expression at the molecular level 3. Explore transmission genetics and solve problems in the transmission of traits 44. Investigate