UNC-Chapel Hill BIOL 252 - Bone Structure (4 pages)

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Bone Structure

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Bone Structure


Intro to Bones

Lecture number:
Lecture Note
University of North Carolina at Chapel Hill
Biol 252 - Fundamentals of Human Anatomy and Physiology

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BIOL 252 1st Edition Lecture 9 Outline of Last Lecture I The Skin Its Structure and Function II The Epidermis III The Dermis IV Hypodermis V Skin Coloration Outline of Current Lecture I The Skin Its Structure and Function Current Lecture I II III Skeleton Function a Protection b Support c Movement d Electrolyte balance i Calcium levels kept stable NT release e Blood formation Histology of Osseous Tissue a Osteogenic cell i Multipotential stem cell b Osteoblast i Blast in a developmental stage ii Complete process of differentiation and become osteocyte c Osteocyte i Live completely surrounded by the matrix they have produced ii Lacunae packet w in bone matrix where osteocytes live iii Interconnect themselves w dendrites arms in canaliculi channels iv Gap junctions allow diffusion and passing along of nutrients d Osteoclasts i Breakdown bone matrix The Matrix a Made of fibers and ground substance b Fibers are proteins c Ground substance is the fluid component of extracellular matrix i Interstitial These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute IV d In bone i Fibers are collagen tough resists stretching ii Ground substance fluid is essentially gone 1 Minerals precipitated out of solution 2 Most is calcium hydroxyapatite calcium phosphate salt 80 of inorganic matrix e Bone in vinegar i Vinegar acetic acid ii Acetic acid calcium phosphate solubilizes the salt iii Illustrates that if you extract mineral component of bone properties of the bone remain same 1 Flexibility comes from collagen 2 Stiffness comes from hydroxyapatite 3 Just removing stiffness f Case 5 year old girl is brought to clinic and legs bend under weight i What could explain this condition at tissue level and what might be cause of tissue abnormality 1 Caused by a Dietary deficiency of calcium b Vitamin D deficiency g Bone Matrix Pathologies i Osteogenesis imperfecta excessively brittle bones

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