UIUC MCB 450 - mcb450 lecture 1 (45 pages)

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mcb450 lecture 1



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mcb450 lecture 1

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Pages:
45
School:
University of Illinois at Urbana, Champaign
Course:
Mcb 450 - Introductory Biochemistry
Introductory Biochemistry Documents

Unformatted text preview:

1 1 MCB 450 Lecture 1 The Unity of Biochemistry Carbon Compounds Stereochemistry Functional Groups Types of Biological Molecules Central Dogma Domains of Life Cellular Organization 1 2 The unity of biochemistry The cell is the basic unit of life All cellular processes can be explained by basic chemical principles Fundamental molecular building blocks are the same One cell differs from another cell but it s all a variation on a theme http www allposters com sp Yeasts and Bacteria Live in Kefir Grains Embedded in KefiranGel They Metabolize the Sugar Posters i9014831 htm http cosmosmagazine com features the promise regeneration 1 3 The unity of biochemistry 1 x 10 6 m 1m Anything found to be true of E coli must also be true of elephants Jacques Monod Nobel Laureate 1 4 Characteristics of Living Systems All living cells can divide All living organisms can replicate their genetic material replicated molecule DNA deoxyribonucleic acid All living organisms convert information stored in DNA into protein via RNA ribonucleic acid Proteins allow cells to transform energy and use it to power biochemical reactions make the biomolecules that they themselves are made of replicate themselves All cells respond to their environment Cellular processes and self assembly of cellular structures are critically dependent on water 1 5 The Elements of Life of total atoms H O C N P S 1 6 Biomolecules Covalent compounds of carbon C forms up to 4 single bonds w other C atoms double triple bonds w other C atoms single bonds w H atoms single double bonds w O N bonds to S P Critical features conferred by covalent bonds atoms are 3 D shape stereochemistry functional groups 1 7 Examples of covalent bonds Two atoms with unpaired electrons in their outer shells can form covalent bonds with each other by sharing electron pairs to fill outer electron shells 1 8 Biologically important covalent bonds formed by carbon free rotation about C C no rotation planar 1 9 D 1 10 Stereochemistry A C containing



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