MCB 450 Introductory Biochemistry http www life illinois edu mcb 450 Login netid Password AD password Course email mcb450help life illinois edu Contact Information Course Instructor Dr Peter Orlean Dept Microbiology B 213 Chem Life Sci Ph 333 4139 p orlean illinois edu Contact Information Course Instructor and Course Coordinator Dr Lyne Levesque Dept Cell Developmental Biol 577 Morrill Hall Ph 333 7565 levesque illinois edu Contact Information Teaching Assistants Xuan Wang xwang174 illinois edu Office Hours TBA Joseph Ly jly5 illinois edu Office Hours TBA Office hours will begin on January 26th Times and location can be found under the instructors link on the website when they become available Required Textbook Biochemistry A Short Course 2nd edition Tymoczko Berg and Stryer W H Freeman and Company New York ISBN 13 978 1 4292 8360 1 Also available as eBook You will need a scientific calculator for the exams and problem sets NO graphing or programmable calculators will be allowed at the exams Basis of Course Grade A 920 1000 A 919 883 A 882 850 B 849 817 B 816 783 B 782 750 C 749 717 C 716 683 C 682 650 D 649 617 D 616 583 D 582 550 F 549 Basis of Course Grade 4 Hourly Exam 150 pts ea Homework 8 x 40 pts ea Pre lecture questions 20 x 4 pts ea Total points possible 600 pts 320 pts 80 pts 1 000 pts Exam Information Three exams will be given during the session Thursdays 7 00 pm 8 50 pm February 12th March 12th and April 9th Exam room assignments can be found under the exams link on the website Final Exam will be given during Finals Friday May 8th from 7 00 pm 10 00 pm It is NOT cumulative Chapters covered on exam given on syllabus Format Mostly Multiple Choice Qs some Short Answer Responses Review sessions will be held in place of lecture before each exam Exam Information Conflicts Illness If you have a conflict with an exam you must fill out a conflict exam request using the form available on the course web site Typical deadline for requesting conflicts is 1 week prior to the exam Conflicts are given on the regular exam day or are prorated If you are ill on the day of an exam see a doctor and when you are well present documentation to Dean of Students If you are ill and chose to take the exam your score will stand Once the Dean has sent you a letter forward it to Dr Levesque Re grades The purpose of re grades is to contest the grading received for a specific question either on one of the LonCapa exercises or Exams Allowed on every assignment and exam except for final exam Download the form fill it out save it and send it back Submit to mcb450help life illinois edu Must be submitted within one week of day assignment returned Course Forms Forms Special Accommodations Special needs due to Disabilities DRES or religious reasons Contact Dr Levesque after class or by email as soon as possible Academic Integrity Your work must be your own Exams Copying will not be tolerated Protect your work May result in grade of zero for exam How to Succeed in this Course Review the following video Strategies for Studying Biology Keep up with reading the textbook Attend office hours on a regular basis Join a study group Emergency Procedures Remember RUN away or HIDE if you can FIGHT if you have no other option Sign up for emergency text messages at emergency illinois edu You ll receive information from the police and administration during these types of situations If you have any questions go to police illinois edu or call 217 333 1216 1 1 MCB 450 Lecture 1 The Unity of Biochemistry Carbon Compounds Stereochemistry Functional Groups Types of Biological Molecules Central Dogma Domains of Life Cellular Organization 1 2 The unity of biochemistry The cell is the basic unit of life All cellular processes can be explained by basic chemical principles Fundamental molecular building blocks are the same One cell differs from another cell but it is a variation on a theme http www allposters com sp Yeasts and Bacteria Live in Kefir Grains Embedded in KefiranGel They Metabolize the Sugar Posters i9014831 htm http cosmosmagazine com features the promise regeneration 1 3 The unity of biochemistry Anything found to be true of E coli must also be true of elephants Jacques Monod Nobel Laureate 1 4 Characteristics of Living Systems All living cells can divide All living organisms uni or multicellular can replicate their genetic material and the replicated molecule is DNA All living organisms convert information stored in DNA into protein via RNA Proteins allow cells to transform energy and use it to power biochemical reactions make the biomolecules that they themselves are made of replicate themselves All cells respond to their environment Cellular processes and self assembly of cellular structures are critically dependent on water 1 5 The Elements of Life of total atoms 1 6 Biomolecules Covalent compounds of carbon C forms up to 4 single bonds w other C atoms double triple bonds w other C atoms single bonds w H atoms single double bonds w O N bonds to S P Critical features conferred by covalent bonds atoms are 3 D shape stereochemistry functional groups 1 7 Examples of covalent bonds Two atoms with unpaired electrons in their outer shells can form covalent bonds with each other by sharing electron pairs to fill outer electron shells 1 8 Biologically important covalent bonds formed by carbon free rotation about C C no rotation planar 1 9 1 10 Stereochemistry A C containing compound can exist as stereoisomers molecules w the same chemical bonds but different configuration fixed spatial arrangement of atoms Configuration is conferred by either 1 Double bonds no freedom of movement around them 2 Chiral centers groups arranged around a C atom in a specific orientation Stereoisomers cannot be interconverted without temporarily breaking one or more covalent bonds 1 11 cis trans configurations geometrical isomers or cis trans isomers 1 12 Chiral molecules four different substituents bonded to a tetrahedral C atom they can be rranged in two different ways in space he asymmetric C atom is called a chiral center Chiral molecule Non superimposable mirror images of one another enantiomers Achiral molecule INTERACTIONS BETWEEN BIOLOGICAL MOLECULES ARE ALMOST INVARIABLY STEREOSPECIFIC 1 13 The D and L system a convention for naming stereoisomers The two stereoisomers of the amino acid alanine enantiomers non superimposable mirror images are L Ala and D Ala The terms L and D come from the direction in which crystals rotate plane
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