Biol 151 Quiz 10 24 14 R Phillis Please enter your name and ID number on your answer sheet accurately This quiz has both multiple choice and multiple true false questions Multiple choice questions have lettered answers Choose the single best answer and enter it on your answer sheet Multiple true false questions have numbered answers Determine whether each answer is true or false and record a for true and b for false on your answer sheet Problem one Which of the following would have either a signal sequence or a nuclear localization sequence T1 SR signal T2 SR receptor F3 TK1 F4 TK2 T5 TFa Problem two The Neuron Receptor is normally a transmembrane protein A mutant form of the protein is secreted from the cell altogether and does not stay in the membrane What could be wrong F6 The signal sequence could be deleted T7 The signal anchor sequence could be deleted F8 The signal recognition protein could be absent F9 The mutant protein could have gained a Nuclear Localization Sequence For the all rest of the questions on this quiz please use the attached diagram of RNA binding protein caused alternative splicing of CDKI 10 Given that the SR Signal causes cell division and the Neuron Signal blocks cell division which signal would cause expression of RNA binding protein a The SR Signal b The Neuron Signal 11 If a signal blocks cell division which gel represents how the mRNA from the CDKI gene would compare to when there is no signal answer a Problem three The CDKI in the diagram can also block cell division in response to damage to structures in the cytoplasm When that damage occurs this CDKI is phosphorylated and then translocated into the nucleus where it blocks the activation of Cdk Other facts about the CDKI Only the longer form of CDKI is translocated into the nucleus Both forms of CDKI are phosphorylated by CDKI Kinase Which of the following must also be true about this CDKI T12 The Nuclear Localization Signal is encoded in exon 3 F13 The Phosphorylation site is located in exon 2 F14 There are no amino acids encoded in exon 1 T15 There is some open reading frame in exon 3 Problem 4 When structures in the cytoplasm are damaged it regulates the expression of RNA binding protein to block cell division Which of the following would properly regulate the RNA binding protein gene T16 Damage in the cytoplasm could cause HAT to target the RNA binding protein gene F17 Damage in the cytoplasm could cause expression of a miRNA that targets the RNA binding protein mRNA T18 When there is no damage in the cytoplasm and cell division is occuring HDAC targets the RNA binding protein gene T19 When there is no damage in the cytoplasm an extra transcription factor binds to the regulatory sequences of the RNA binding protein gene that block the TATA box 20 Which of the following represent the mRNA from CDKI when the RNA binding protein gene is expressed answer b