Microbio 310 1st Edition Lecture 1 Outline of Current Lecture I. MRSAII. Griffith’s Transformation ExperimentIII. 1.1 The Science of MicrobiologyCurrent LectureMRSA (methicillin resistant staphylococcus aureus)- Methicillin-resistant bacteria- Picked up a gene that will detoxify methicillin- Resistance happens b/c bacteria divide all the time mistakes happen in DNA replication create new strains resistant to antibiotics- Resistance is inevitableGriffith’s Transformation Experiment- Mouse injected with living S strain bacteria (virulent)o Mouse dies of pneumonia- Mouse injected with living R strain bacteria (nonvirulent)o Mouse lives- Boil/kill S strain bacteriainject into mousemouse alive- Mix dead S strain with living R straininject into mouseMouse dies by pneumonialiving S strain found in heart- Dead S strain transformed to live S strain- DNA=transforming factor- Conclusion: chemical substance from one cell capable of genetically transforming another cell1.1 The Science of Microbiology - Microbiology has two major themes: 1. Understanding basic life processes These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.• Microbes are excellent models for understanding cellular processes in unicellular and multicellular organisms o Cheaper to grow, lots of them2. Applying that knowledge to the benefit of humans • Microbes play important roles in medicine, agriculture, and industry o Ex: We make human insulin from microbes1.1 The Science of Microbiology• The Importance of Microorganisms:– Oldest form of life– Largest mass of living material on Earth– Carry out major processes for biogeochemical cycles– Can live in places unsuitable for other organisms (ex: found on outside of space station)– Other life forms require microbes to survive (i.e. humans)o You can be typed based on the microbes that live on you=microbial
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