Regulation of stem cell self renewal and differentiation Nghi Nguyen Biochemistry 118Q Spring 2007 Outline Adult Stem Cells Maintenance Asymmetric Cell Division Stem Cell Niche GSC Dpp Bam Cancer Adult Stem Cells Maintenance Repair Blood Skin Neurons Fuller DBIO 210 Spring 2007 Alternate Cell Fates Fuller DBIO 210 Spring 2007 Asymmetric Cell Division Intrinsic factor s and or Extrinsic factor s Niche Fuller DBIO 210 Spring 2007 Stem Cell Niche Science 290 5490 328 330 Female Drosophia Germanium GSC Niche secretes TGF Differentiation requires Bam BamNiche Dpp Gbb S S SS SS S S S S S S Cb O Fuller DBIO 210 Spring 2007 Dpp prevents differentiation Cell 94 251 260 1998 Loss of TGF in niche O control Germaria with a marked stem cell mutant days Science 290 328 330 2000 TGF signaling promotes self renewal by modulating differentiation Dpp bam off GSC GSC cyst on bam Cb O Fuller DBIO 210 Spring 2007 A Bad Environment Cancer Stem Cells Uncontrolled symmetrical division Nature 441 1068 1074 2006
View Full Document
Unlocking...