Study Guide: Terms and Definitions
34 Cards in this Set
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Hexokinase -location -what rxn -cofactors?
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in most tissues
glucose --> glucose-6-phosphate
ADP -->ATP
Mg2+
IRREVERSIBLE
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phosphoglucoisomerase (PGI) -rxn -cofactors?
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G6P-->Fructose-6-phosphate
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Glucokinase -location -rxn -cofactors
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LIVER
Glu-->G6P
ADP-->ATP
IRREVERSIBLE
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PFK1 -rxn -cofactors
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F6P-->F1,6BP
ADP-->ATP
Mg2+
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Aldolase -rxn
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F1,6BP -->DHAP + GA3P
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GA3P DH + TIM -rxn -cofactors
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DHAP + GA3P --> 1,3BPG
NAD+-->NADH
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PGK -rxn -cofactors
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1,3BPG ---> 3PG
ADP-->ADP
Mg2+
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PGM -rxn -cofactors
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3PG --> 2PG
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Enolase -rxn -cofactors
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2PG --> PEP
H20 created
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Pyruvate Kinase -rxn -cofactors
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PEP --> Pyruvate
ADP--> ATP
IRREVERSIBLE
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What inhibits Hexokinase
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G6P
Direct Feedback Inhibition
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What inhibits Glucokinase
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F6P
Indirect Feedback Inhibition
**F6P inhibition blocked by F1P
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What enzyme makes F6P --> F2,6BP
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PFK2
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What inhibits PFK1
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ATP (this inhibition blocked by AMP)
Citrate
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What activates PFK1
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F2,6BP
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What inhibits Pyruvate Kinase
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ATP
Alanine
Acetyl-CoA
Hormones (in liver)
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What activates Pyruvate Kinase
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AMP
F1,6BP
Insulin (in liver)
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Citrate Synthase
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Oxal + Acetyl-CoA --> Citrate
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aconitase
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Citrate --> Isocitrate
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Isocitrate DH
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Isocitrate --> a-KG
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a-KG DH
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a-KG --> Succinyl CoA
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Succinyl-CoA Synthetase
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succinyl CoA --> Succinate
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succinate DH
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succinate --> Fumarate
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fumarase
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fumarate --> malate
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malate DH
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malate --> oxal
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what 3 steps produce NADH
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isocitrate DH
a-KG DH
Malate DH
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What step produces the CO2 from oxal end C#1
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isocitrate DH
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What step produces the CO2 from oxal end C#4
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a-KG DH
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what step produces GTP
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succinyl-CoA synthetase
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what 3 steps are irreversible?
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citrate synthase
isocitrate DH
a-KG DH
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What two enzymes cause Pyruvate --> PEP
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pyruvate carboxylase makes pyruvate into oxal
PEPCK makes oxal into PEP
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What are two steps needed to go from Pyruvate --> PEP
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Very high energy step in the glycolysis direction
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What enzyme takes F1,6BP --> F6P
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fructose bisphosphatase
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What enzyme takes G6P --> Glucose
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glucose-6-phosphatase
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Gluconeogenesis - Flashcards