BCHM 307 1st Edition Lecture 34 Outline of Last Lecture I Mitochondria II Pyruvate Dehydrogenase Complex III Steps of the Citric Acid Cycle Outline of Current Lecture I Citric Acid Cycle Anabolism A Respiration II Electron Transport A Three Dependent Factors Current Lecture This lecture finishes up the citric acid cycle and then moves onto the electron transport system After all the steps of the citric acid cycle are done there are some products made NADH hydrogen ions and FADH2 are produced These will be used to produce ATP After the step that makes succinyl CoA GTP is formed This can also be used to make ATP There is also the topic of anabolism to cover The products made from the citric acid cycle can be used to build up other molecules Citrate can be used to make fatty acids and cholesterol Alphaketoglutarate can be used to make amino acids and nucleotides Malate can be used to regenerate pyruvate Succinyl CoA can be used to makes hemes Oxaloacetate can make glucose as well It is important to note that the term respiration refers to the process in which cellular energy is generated through the oxidation of nutrient molecules with oxygen as the ultimate electron acceptor Up until this lecture the focus has been on the production of carbon dioxide We will finally move onto oxygen and the electron transport chain Electron transport and oxidative phosphorylation both capture the energy of NADH and FADH2 through the oxidation reduction potential This captured energy is used to produce ATP This coupling of reactions to produce ATP depends upon three factors 1 The sequential redox reactions have to pass the electrons from NADH and FADH2 to oxygen 2 These reactions are compartmentalized in the mitochondrion 3 The proton gradient is generated from the above These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute The electron transport chain occurs in the membrane of the mitochondria as opposed to the mitochondrial matrix as before
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