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Purdue BCHM 30700 - Mitochondrial Electron Transport Chain
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Lecture 35Outline of Last Lecture I. Citric Acid Cycle AnabolismA. RespirationII. Electron TransportA. Three Dependent Factors Outline of Current Lecture I. Mitochondrial Electron Transport ChainII. Reduction PotentialIII. The Four ComplexesIV. Flow of ElectronsCurrent Lecture This lecture will continue on with information about the mitochondrial electron transport chain. The electron transport chain is based upon a series of oxidation-reduction reactions in a sequential order. In this system, the electrons start with NADH. These electrons will get passed, one at a time, to FADH2 and then to oxygen. The electron transport system also occurs in photosynthesis. The compounds throughout these systems have different rates at which they are oxidized or reduced. The way to compare these rates is by the measure of redox potential, E°’. The equation that links this all together is:∆G°’ = -nF ∆E°’Where n is the number of electrons transferred and F is the Faraday constant. The electron transport chain releases the potential energy of NADH and FADH2 in a stepwise manner. This occurs through the use of four main complexes. As the electrons go from complex 1 to 4, the measure of redox potential decreases. The tendency of the complex to donate electrons increases from complex 4 to 1. It is important to note that complex 1 and 2 are separate complexes, even though they end up coming together at complex 3. The greater the reduction potential, the more oxidized the molecule is. The electron transport chain is associated with the mitochondrial inner membrane. Remember that theTCA cycle occurs in the mitochondrial matrix. The electron flow starts with NADH and flows through complex one. Complex two is another way of starting the chain. It starts with the FADH2 generated in the TCA cycle. Both complex one and two then meet at coenzyme Q. This is not a protein but a lipophilic molecule. It is also classified as a membrane localized, low molecular weight compound. Complex 3 is where the electrons go next. They then flow through cytochrome C. This is a peripheral membrane protein that carries heme groups and can absorb light. The cytochromes are a type of protein components that use metal-containing prosthetic groups. Finally, the electrons travel through complex four and to oxygen. Complex four is a type of integral membrane protein. BCHM 307 1nd EditionThe electron transport chain also includes proteins that contain flavins to carry electrons. These can be iron-sulfur containing proteins. The sulfurs come from cysteine residues in the


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Purdue BCHM 30700 - Mitochondrial Electron Transport Chain

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