MOLECULAR BIOLOGY AND BIOCHEMISTRY 694:408:/115:511LECTURE SCHEDULE – SPRING 2005Time & Place: -- TF2 (9:50-11:10 AM); SEC 111, BuschCourse Coordinator: -- Prof. Robert A. Niederman (A317 Nelson, 445-3985)Grades will be posted on the MBB Department website: http://www.rci.rutgers.edu/~molbio/Lecture Date Lecturer Topic Chapter* 1 1/18 Vershon Transcription & its Control in Prokaryotes Watson 12 (Pp. 347-362)‡ 2 1/21 " " " Watson 16 3 1/25 Transcription & its Control in Eukaryotes Watson 12 (Pp. 363-377) 4 1/28 " " " Watson 17 5 2/1 " " " " 6 2/4 Gunderson Post-Transcriptional Control: Splicing, Polyadenylation Watson 13‡2/8 FIRST EXAMINATION -- Covers Lectures 1-5 7 2/11 Post-Transcriptional Control: Splicing, Polyadenylation (cont’d) “ 8 2/15 '' " " " " “9 2/18 RNA World, Ribozymes, RNA Splicing “10 2/22 Control of mRNA Translation, Stability, Localization Watson 1411 2/25 Translation: Prokaryotic & Eukaryotic Watson 14, 1512 3/1 Niederman Membrane Transport 10*9(Pp. 284-306)**3/4 SECOND EXAMINATION -- Covers Lectures 6-1113 3/8 Light Reactions of Photosynthesis 22*21**14 3/11 Lipid Metabolism -- Fatty Acid Oxidation & Biosynthesis 24,25*23,24**15 3/22 Phospholipids & Steroids 25*24**16 3/25 Protein Secretion & Targeting 33(Pp 1116-25)*31**‡17 3/29 Protein Turnover "18 4/1 Signal Transduction 34(Pp. S0-S26)*32(Pp 1041-1066)**19 4/5 Review Session4/8 THIRD EXAMINATION -- Covers Lectures 12-1820 4/12 Deis Gluconeogenesis & Glycogen 15,23*15,22**21 4/15 Pentose Phosphate Pathway 23*22**22 4/19 The Urea Cycle 26*25**23 4/22 Amino Acid Biosynthesis 26*25**24 4/26 Amino Acid Catabolism/Purines 26,27*25,26**25 4/29 Nucleotide Metabolism 27*26**5/5 (Noon) FOURTH EXAMINATION -- Covers Lectures 20-25 Required Texts: *Garrett, R.H. & Grisham, C.M. (1999) Biochemistry, 2nd Ed., Saunders; ** Garrett, R.H. &Grisham, C.M. (2005) Biochemistry, 3rd Ed., Thomson (on reserve at LSM and SEC Library for those with 2ndEd.); Watson, J.D., et al. (2004) Molecular Biology of the Gene, 5th Ed., Benjamin Cummings.‡Supplementary readings will be provided.Molecular Biology and Biochemistry 694:407-408 is offered as the primary lecture courses for undergraduatestudents in the Molecular Biology and Biochemistry major, as well as for non-majors who wish to enroll in acontemporary, comprehensive two-semester course in these rapidly developing disciplines. Biochemistry115:511-512 mainly serves graduate students in Graduate Programs other than Biochemistry. Students in theBiochemistry Graduate Program should take 115:501-502.-2-The Lecturers can be consulted for additional assistance by appointment or during office hours: Phone No. E-Mail Dr. Frank H. Deis Tuesdays 12-2 A311 Nelson 445-2814 [email protected]. Andrew K. Vershon By appointment 0234 Waksman 445-2905 [email protected]. Sam Gunderson By appointment A322 Nelson 445-1016 [email protected]. Robert A. Niederman By appointment A317 Nelson 445-3985 [email protected] examinations will be given at the end of each series of lectures on the indicated dates during regularclass hours; the first three will be given in assigned seats in the classroom and in a second classroom to bedetermined. The fourth hourly examination is scheduled for Thursday May 5th from 12:00 PM to 3:00 PM,during the final exam period, in a room to be announced -- there will be no cumulative final exam. All examswill be graded promptly and the grades and answer keys will be posted on the Department website:http://www.rci.rutgers.edu/~molbio/. All four examinations will be averaged and weighted equally in assigningfinal grades.Requests for corrections of exam grading will only be considered within a week after exam papers have beenreturned. Students who are unable to take an hourly exam at the scheduled time because of compellingreasons supported by documentation, such as a note from their Physician, may be permitted to take a make-up examination. It should be realized that Professors will have discretion in penalizing make-up tests. Arrange-ments should be made with Prof.