694:408: MOLECULAR BIOLOGY AND BIOCHEMISTRYLECTURE SCHEDULE – SPRING 2004Time & Place: -- TF2 (9:50-11:10 AM); SEC 111, BuschCourse Coordinator: -- Prof. Robert A. Niederman (A317 Nelson, 445-3985)Grades will be posted on the MBB Department website: http://www.rci.rutgers.edu/~molbio/Lecture Date Lecturer Topic Chapter* 1 1/20 Vershon Transcription & its Control in Prokaryotes 31‡ 2 1/23 " " " 3 1/27 Transcription & its Control in Eukaryotes " 4 1/30 " " " " 5 2/3 " " " " 6 2/6 Gunderson Post-Transcriptional Control: Splicing, Polyadenylation ‡2/10 FIRST EXAMINATION -- Covers Lectures 1-5 7 2/13 Post-Transcriptional Control: Splicing, Polyadenylation (cont’d) 31 (1057-1066) 8 2/17 '' " " " " ‡9 2/20 RNA World, Ribozymes, RNA Splicing 14 (Pp. 454-7) ‡10 2/24 Control of mRNA Translation, Stability, Localization ‡11 2/27 Translation: Prokaryotic & Eukaryotic 32, 33 (Pp. 1089-1115) ‡12 3/2 Niederman Membrane Transport 103/5 SECOND EXAMINATION -- Covers Lectures 6-1113 3/9 Light Reactions of Photosynthesis 2214 3/12 Lipid Metabolism -- Fatty Acid Oxidation & Biosynthesis 24, 2515 3/23 Phospholipids & Steroids 2516 3/26 Protein Secretion & Targeting 33 (Pp. 1116-25)‡17 3/30 Protein Turnover "18 4/2 Signal Transduction 34 (Pp. S0-S26)19 4/6 " " "20 4/9 Deis Gluconeogenesis & Glycogen 15, 234/13 THIRD EXAMINATION -- Covers Lectures 12-1921 4/16 Pentose Phosphate Pathway 2322 4/20 The Urea Cycle 2623 4/23 Amino Acid Biosynthesis 2624 4/27 Amino Acid Catabolism/Purines 26, 2725 4/30 Nucleotide Metabolism 275/6 (Noon) -- FOURTH EXAMINATION -- Covers Lectures 20-25 *Required Text: Garrett, R. H. & Grisham, C. M. (1999) Biochemistry, 2nd Ed., Saunders. ‡Supplementary readings will be provided.Biochemistry 694:407-408 (Molecular Biology and Biochemistry) are the primary lecture courses for studentsin the Molecular Biology and Biochemistry major, as well as for non-majors who wish to enroll in a contempor-ary, comprehensive two-semester course in these rapidly developing areas.-2-The Lecturers can be consulted for additional assistance by appointment or during office hours: Phone No. E-Mail Dr. Frank H. Deis Tuesdays 12-2 A311 Nelson 445-2814 [email protected]. Andrew K. Vershon By appointment 0234 Waksman 445-2905 [email protected]. Sam Gunderson By appointment A322 Nelson 445-1016 [email protected]. Robert A. Niederman By appointment A317 Nelson 445-3985 [email protected] examinations will be given at the end of each series of lectures as indicated in the syllabus; the firstthree will be given in the classroom and in a second classroom to be assigned on the indicated dates duringregular class hours. The fourth hourly examination is scheduled for Thursday May 9 from 12:00 PM to 3:00PM, during the final exam period, in a room to be announced -- there will be no cumulative final exam. Allexams will be graded promptly and the grades and answer keys will be posted outside the Department office(A321 Nelson) and on the Department website. All four examinations will be averaged and weighted equally inassigning final grades.Requests for corrections of exam grading will only be considered within a week after exam papers have beenreturned. Students who are unable to take an hourly exam at the scheduled time and have a valid writtenexcuse, such as a note from their Physician, may be permitted to take a make-up examination. Arrangementsshould be made with Prof.