ABIO 350 Fundamental Genetics Syllabus Fall 2007 - 1 - Instructor: Dr. William H. Jackson Office: SBDG 201A Office hours: By appointment Telephone: 641-3601 Email: [email protected] Lecture: TTH,8:00-9:15 in SBDG 200 Text: Genetics: From Genes to Genomes, 3rd Edition by Hartwell, et al. Writing Papers in the Biological Sciences., 4th Edition by McMillan Laboratory: M,10:00-12:40 in SBDG 108 See Laboratory Syllabus Supplies: Scantron Sheets, laboratory notebook, and Scientific calculator Credit: Four (4) Semester Hours Course Description: Fundamental Genetics is a four credit hour course for biology majors, which covers the principles of transmission, molecular, and population genetics. Topics covered will include Mendelian genetics, quantitative inheritance, linkage, recombination, the biochemical aspects of gene function and regulation, and developmental and population genetics. Course Objectives: This course will introduce the student to the underlying principles of genetics. It is divided into transmission and molecular genetics. On completion of this course students will be expected to 1. Demonstrate an understanding of transmission genetics; 2. Demonstrate an understanding of molecular genetics; 3. Demonstrate an ability to write and discuss applications of genetic concepts; 4. Prepare written and oral reports of hereditary data 5. Solve genetics problems using appropriate mathematical techniques in conjunction with data collected in the genetics laboratory; Attendance Policy: Students are expected to adhere to the University attendance policy as stated in the Student Handbook. In this regard, the instructor may impose a penalty for absences in excess of 25% of regularly scheduled class meetings by assigning an “F” in the course. Absences, neither excused not unexcused, absolve the student from meeting class assignments. Because of their nature, laboratory exercises cannot be made up – students should make every effort to attend all laboratory sessions. Disability Statement: If you have a physical, psychological, and/or learning disability, which might affect your performance in class, please contact the Office of Disability Services, 126A B&E (803) 641-3609, as soon as possible. The Disability Services Office will determine appropriate accommodations based on medical documentation. Methods of Presentation and Evaluation: Information will be presented through lectures, class discussions, and laboratory exercises using appropriate visual aids and equipment. Several assignments and some course materials will be handled through Blackboard. The final course evaluation will be based on the following weighted assignments: Description Percentage Comments Two 1-hr exams 30% 300 points (each exam = 15%) Genetics Problem set 15% 150 points (Transmission genetics problems) Final Exam 15% 150 points (Comprehensive final exam) Quizzes 15% 150 points (Material discussed the previous 1 – 2 weeks) Laboratory 25% 250 points See Laboratory Syllabus supplement The letter grades will be based on total accumulated points and will be assigned as follows: A>900; B>800; C>650; D>550; F<550. Biology majors must make a C or better in this core course.ABIO 350 Fundamental Genetics Syllabus Fall 2007 - 2 - TENTATIVE LECTURE SCHEDULE Date Week Topic/Comments Chapter Aug 23 1 Mendel’s Breakthrough 2 Aug 28 Aug 30 2 Lecture quiz 1; Mendel’s Breakthrough Extensions to Mendel 2 2 Sep 4 Sep 6 3 Lecture quiz 2; Extensions to Mendel Extensions to Mendel 3 3 Sep 11 Sep 13 4 Lecture quiz 3; The Chromosome Theory of Inheritance The Chromosome Theory of Inheritance 4 4 Sep 18 Sep 20 5 Lecture quiz 4; Linkage and Mapping Linkage and Mapping 5 5 Sep 25 Sep 27 6 Lecture Quiz 5; Linkage and Mapping Linkage and Mapping 5 5 Oct 2 Oct 4 7 Exam I DNA: Recombination and Replication 2-5 6 Oct 9 Oct 11 8 Lecture Quiz 6; DNA: Recombination and Replication Fall Break (Oct 11 – 12) 6 Oct 16 Oct 18 9 DNA: Recombination and Replication DNA: Recombination and Replication 6 6 Oct 23 Oct 25 10 Lecture Quiz 7; DNA: Recombination and Replication DNA: Recombination and Replication 6 6 Oct 30 Nov 1 11 Lecture Quiz 8; Gene Expression Gene Expression 8 8 Nov 6 Nov 8 12 Lecture Quiz 9; Gene Expression Gene Expression 8 8 Nov 13 Nov 15 13 Exam II Gene Expression 6-8 8 Nov 20 Nov 22 14 Gene Expression Thanksgiving Holiday (Nov 21 – 23) 8 Nov 27 Nov 29 15 Lecture Quiz 10; Gene Expression Biotechnology 8 9 Dec 4 Dec 6 16 Biotechnology Biotechnology 9 9 Dec 13 Final Exam at 8:00 AM ComprehensiveYou will be expected to endorse the USCA HONOR PLEDGE on every assignment: 'On my honor as a University of South Carolina Aiken student, I have neither given nor received any unauthorized aid on this assignment/examination. To the best of my knowledge, I am not in violation of academic honesty' General Information: Genetics Laboratory is not separate from Genetics Lecture; therefore, students are expected to synthesize the material covered in lecture, laboratory, and the text. Each student is expected to meet every laboratory session, as it is impossible to recreate the laboratory setup after the scheduled meeting time. In general, each laboratory meeting will be divided into up to three independent sessions. The first session, lasting approximately one hour, will be used to extend lecture materials. The second session will typically be used to answer questions and solve genetics problems. The third session will be used to carry out the assigned laboratory exercise. Several laboratory meetings will be required to work on genetic crosses between mutant strains of Drosophila melanogaster, which will require several weeks to complete. Because the laboratory studies involve living systems, the student must be prepared to work on the project when the need arises. While some of the work can be done during normal laboratory meeting times, this is not always the case. A second major component of genetics laboratory is a research project on a specific genetic disease. For this, a disease topic will be provided by the instructor. Students will use this topic to write a one-page summary that includes at least three references from peer-reviewed journals and/or medical textbooks. References must be cited using CSE format (Chapter 4 in the supplemental text). Students will also give a 10-minute oral presentation of theirABIO 350 Fundamental Genetics Syllabus Fall 2007 - 3 - topic