Slide 1Slide 2Slide 3Slide 4Slide 5Transport of Blood GassesOxy-Hemoglobin Dissociation CurveSlide 8Respiratory ControlCommentsSlide 11IE 5531IE 553 Engineering of Human WorkDr. Andris FreivaldsClass #25IE 5532IE 553 Engineering of Human WorkDr. Andris FreivaldsClass #25IE 5533IE 5534IE 5535IE 5536Transport of Blood Gasses•Transport of O2: RBC & plasma → muscle –oxyhemoglobin (99%)–dissolved in water (1%)•Transport of CO2: muscle → RBC & plasma–carbonic acid (buffering system, 81%)–carbamino hemoglobin (11%)–dissolved in water (8%)Muscle cell Interstitial fluid Plasma & RBCCO2CO2CO2O2O2O2IE 5537Oxy-Hemoglobin Dissociation CurveO2 carrying capacity ↑:1)↓O22)↑CO2, (↑H+)IE 5538Oxy-Hemoglobin Dissociation CurveCO2 EffectpH EffectTemp EffectCO EffectO2 capacity ↑:1)↑ temp2) ↑H+, (↑CO2)IE 5539Respiratory Control1) medulla - inspiratory/expiratory center, rhythmic reciprocal control2) peripheral chemoreceptors - carotid and aortic arch, ↓O2 increases rate3) central chemoreceptors - medulla, ↑CO2 and ↑H+ increase rate4) stretch receptors in lungs - controls volume of respirationIE 55310Comments•hypoxia - lack of oxygen•acclimatization - ↑alveolar ventilation through ↑hemoglobin, ↑red blood cells, shift in oxyhemoglobin curve•second wind - clearing of accumulated metabolites•underwater: bends, nitrogen narcosis, hyperventilation•emphysema - breakdown of alveolar walls•asthma - constriction of bronchiolesIE 55311Hypoxia → shift
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