Biology 311 Human Genetics Fall 2006 Instructor Office Office Hours Phone email Web Page Lectures Dr Nancy J Bachman 35 Denison Hall MWF 11 am 12 noon 436 3061 bachman oneonta edu http employees oneonta edu bachman human 20genetics biology 311web htm MWF 9 9 50 am HECO 127 Lecture Schedule week date lecture topic 1 8 23 8 25 8 28 8 30 9 1 9 4 9 6 9 8 9 11 9 13 9 15 9 18 9 20 9 22 DNA RNA proteins review Chromosomes Chromosome defects Pedigree analysis Complex traits Hardy Weinberg equilibrium Recombinant DNA Recombinant DNA Recombinant DNA Recombinant DNA Recombinant DNA Recombinant DNA Recombinant DNA Human genome project 9 25 9 27 Bioinformatics Model organisms 9 29 mtDNA 10 2 10 4 Fall Break I no class Nuclear gene organization 10 6 10 9 10 11 10 13 Regulation of gene expression Regulation of gene expression Mutation and repair Mutation and repair 2 3 4 5 6 7 8 1 text assignment Chap 1 Chap 2 Chap 4 Chap 5 Chap 6 Chap 7 Chap 8 to p 226 Chap 8 pp 226 235 Chap 9 to p 244 Other assignments Study questions Methods topic Article 1 Problem set Methods presentations First take home exam due Skim Article 2 Chap 9 pp 244 272 Chap 10 Chap 10 Chap 11 Chap 11 9 10 11 12 13 14 15 16 17 10 16 Comparing genes and genomes 10 18 Gene mapping 10 20 Positional cloning 10 23 Complex diseases 10 25 Molecular pathology 10 27 Molecular pathology 10 30 Cancer genetics oncogenes Chap 12 11 1 11 3 11 6 11 8 11 10 11 13 11 15 11 17 11 20 11 22 11 24 11 27 11 29 12 1 12 4 12 6 12 13 Chap 18 Chap 19 Chap 20 Cancer genetics suppressors DNA testing DNA profiling Functional genomics Proteomics Stem cells cloning Knock outs transgenics RNAi Fall Break III no class Fall Break III no class Fall Break III no class Gene therapy Presentations Presentations Presentations Presentations Final exam 8 am 10 30 am Chap 13 Chap 14 Chap 15 Chap 16 Chap 17 Problem Set 2 Second take home exam due Review paper topic Chap 21 Review papers due Final take home Exam due Course Description Biological basis for human heredity Course will examine the transmission of traits in human lineages pedigree analysis the molecular basis for genetic disease molecular genetics chromosomal defects cytogenetics and genetic variation in populations population genetics Current topics such as the human genome project cloning and stem cell research DNA forensics and gene therapy will be discussed Course Objectives 1 Review key concepts in molecular Mendelian and population genetics relevant to the study of human heredity 2 Develop skills in critical thinking and problem solving based on aspects of genetics 3 Highlight how the human genome project and new tools in molecular biology are impacting human genetic and reproductive technologies 2 Required Text Strachan Tom and Read Andrew P 2004 Human Molecular Genetics 3 third edition Garland Science New York NY Required Readings Research articles will be available on blackboard or in some cases can be downloaded directly from the web Lecture and Exam Schedule The class meets MWF 9 9 50 am in room 319 Science I There will be three take home exams These will be handed out about a week before they are due The third take home will be due at the time scheduled for the final exam Problem Sets A major objective of this course is to encourage you to think critically about genetics Problem sets will occasionally be assigned and worked in class Several questions on the take home exams will be problems Methods Presentations Early in the semester we will focus on a number of recombinant DNA methods You will choose a particular method and investigate it further including how it might be applied in human genetics You will provide a class handout paper or electronic and brief presentation in class 10 15 min on the method Images can be used from the text to illustrate your presentation and are available on blackboard Research Articles During the semester we will be reading and discussing as a group two research articles You will hand in a review of major points from the paper using the format in an upcoming class handout For extra credit up to 20 points you can choose to review an additional research article you obtain from the instructor Review paper and presentation Details of this assignment will be given in an upcoming class handout Identify early in the semester a topic in human genetics to research The review paper will involve selecting a focus paper which must be a published review or research article and additional related references including articles books and internet sources You will summarize major points of the article and provide additional background relevant to the topic You will also give about a ten minute power point presentation to the class on your topic The paper will be due Nov 29 2006 and presentations will be given during the last five class periods Grading Take home exams 3 80 pts each 240 pts Problems and study questions 60 pts Methods presentation 20 pts 3 Article reviews 2 40 pts extra credit option Review paper and presentation 80 pts Course total 440 pts Grades will be assigned based on the following of the course point totals A 93 100 C 73 76 A 90 92 C 70 72 B 87 89 D 67 69 B 83 86 D 63 66 B 80 82 D 60 62 C 77 79 E 60 4