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body's maximal ability to take-up, transport, and utilize oxygen
VO2max 
the raw amount of oxygen a body consumes
absolute VO2max 
units for absolute VO2max
L/min 
amount of oxygen a person consumes relative to their body weight
relative VO2max 
units for relative VO2max
mL/kg*min 
the 2 physiological factors that influence VO2max
1. central component 2. peripheral component 
the maximum ability of the cardiorespiratory system to deliver oxygen to the working muscles
central component (cardiac output) 
the physiological component of VO2max that deals with how we transport oxygen
central (lungs, blood, heart) 
amount of blood ejected by the heart per minute
cardiac output (HR * SV) 
amount of times the heart beats per minute
heart rate 
amount of blood ejected by the heart per beat
stroke volume 
the muscle's ability to take up the oxygen and produce ATP aerobically
peripheral component (how we utilize O2) 
what 4 areas make up the peripheral components of VO2max
1. a-v difference 2. muscle fibers 3. capillary density 4. mitochondria 
VO2max is the gold standard for determining __________
cardiovascular fitness 
T/F: VO2max is the greatest predictor of all causes of mortality
true 
for every L of O2 consumed per minute, approximately ___ kcalories have been expended
5 
the point which blood lactate suddenly rises during exercise
lactate threshold (mmoles/L) 
_____ is the most powerful predictor of exercise capacity in elite athletes with similar VO2max values
lactate threshold 
_______ represents the greatest work output that can be sustained over an extended period of time
lactate threshold 
____ exponentially increases with an increasing exercise intensity
lactate threshold 
resting lactate is measured at ___
1-2 millimoles/L 
Factors that are responsible for there being a lactatethreshold
1. low muscle oxygen 2. accelerated glycolysis 3. recruitment of fast-twitch fibers
Body's 3 fuel sources
1. carbohydrates 2. Lipids 3. Proteins 
body's carbohydrate fuel sources are
1. blood glucose (stored as glycogen) 2. muscle glycogen 
body's fatty fuel source
1. Plasma FFA (from adipose tissue lipolysis) 2. Intramuscular triglycerides 
protein fuel sources contribute only ___% of total energy production
2% 
glucose levels need to be at ______mg/dL of blood
70-100 
disorder classified as having blood glucose levels below 70-100mg/dL of blood
hypoglycemic 
disorder classified as having blood glucose levels above 70-100 mg/dL
hyperglycemic 
disorder classified as having blood glucose levels chronically at 100-125 mg/dL
prediabetes 
2 main factors that determine fuel source used
1. intensity 2. duration 
what is the main fuel source used for low-intensity exercise?
fats 
low-intensity exercise is considered to be <_____% of VO2max
30% 
high-intensity exercise is considered to be >___% of VO2max
70% 
what is the main fuel source used for high-intensity exercise
Carbs 
describes the shift from fat to carbohydrate metabolism as exercise intensity increases
crossover concept 
what are the causes responsible for the shift form fat to carb metabolism as exercise intensity increases
1. recruitment of fast muscle fibers 2. increasing blood levels of epinephrine (stimulates glycolysis) 
volume of CO2 / volume of O2 is known as
the respiratory exchange ratio (RER) 
____ is known to modify the amount of kcals expended during exercise
type of substrate used 
RER of .7 indicates...
100% fat utilization 
RER of .85 indicates...
50% fat, 50% CHO utilized (cross-over) 
RER of 1.00 indicates...
100% CHO 
type of fat used most at the lower intensity is ____
plasma FFA (free fatty acids) 
why is there a shift from CHO to fat metabolism during prolonged exercise after 2-3 hours?
1. reduced rates of glycolysis and pyruvate 2. increased rate of beta-ox 
the walls of the heart from outermost to innermost
pericardium> epicardium >myocardium>endocardium 
cardiac protective sac that contains pericardial fluid
pericardium 
outer layer of the heart is known as
epicardium (flattened epithelial cells & CT) 
middle layer of the heart that is actually the thickest layer and is known as the cardiac muscle
myocardium 
inner layer of the heart
endocardium (flattened epithelial cells and CT) 
list the 4 chambers of the heart
1. right atrium 2. left atrium 3. right ventricle 4. left ventricle 
the 2 heart valves on the right chamber of the heart
1. tricuspid valve 2. pulmonary semilunar valve 
the 2 valves on the left chamber of the heart
1. bicuspid valve 2. aortic semilunar vlave 
side of the heart that deals with the pulmonary circuit
right side 
side of the heart that deals with the systemic circuit
left side (why left wall is much thicker) 
T/F: cardiac muscle fibers are involuntary
true 
path of action potential in the heart
Sinoatrial node> AV node>>bundle of His>> R/L bundle branches >>purkinje fibers 
the heart's natural pacemaker
SA node 
____ innervate the myocardium of the ventricles and trigger them to contract
purkinje fibers 
specialized gap junctions that are located b/w individual cardiac muscle fibers and allow for the action potential to spread across the unit
intercalated discs 
3 features that differentiate cardiac muscle from skeletal muscle
1. involuntary 2. longer refraction period 3. more mitochondria 
the relaxation phase of the heart during which it fills with blood
diastole 
at rest, diastole is longer than systole by _____
2x 
the phase of the cardiac cycle in which the heart ejects blood
systole 
T/F: as heart rate increases, the duration of cardiac cycle decreases
true 
during exercise, ______ is 2x longer than ______-
systole; diastole 
pathway of blood to and from the heart
heart>>arteries>>arterioles>> capillaries >>venules>>veins 
site of nutrient exchange from blood to organs occurs at
capillaries 
2 major arteries that supply blood to the myocardium
left/right coronary arteries (left is bigger) 
layers of the arteries are known as
lumen 
outermost layer of arteries composed of CT
tunica adventitia 
contractile portion of the arteries; composed of smooth muscle
tunica media 
increase in the diameter of the artery
vasodilation 
decrease in the diameter of the artery
vasoconstriction 
layer of lumen that lines the inner layer of the arteries; composed of endothelial cells
tunica intima 
layer of lumen that contains chemicals
tunica intima 
disease that explains the buildup of fat within the coronary arteries which occludes blood flow resulting in a heart attack
Coronary Artery Disease (CAD) 
hardening of the arteries that occurs with an increase in age
arteriosclerosis 
form of arteriosclerosis in which the arteries harden due to fat build up
arteriosclerosis 
pressure of the circulating blood against the walls of the vasculature
blood pressure 
healthy blood pressure is considered to be..
<= 120 (systole)/80 (diastole) 
what classifies as hypertension
systolic over 140 mmHg
what is the equation for blood pressure
BP = Q (cardiac output) x TPR 
what is the equation for cardiac output
Q= SV x HR 
what is the equation for SV
SV= EDV-ESV 
amount of blood left in the ventricles at the very end of the diastolic phase
End Diastolic Volume 
List the three factors affecting HR
1. intrinsic automaticity 2. cardiovascular autonomic control 3. circulating neurohormones 
the pressure the heart faces when it contracts is known as
TPR "afterload" 
the amount of blood the heart needs to pump to overcome rest and contract
systolic BP 
the heart depolarizes at a rate b.w _________ bpm
60-100 bpm 
autonomic branch of the nervous system that decreases heart activity
parasympathetic nervous system (PNS) 
AcH is released in response to which autonomic system
parasympathetic 
autonomic branch of the nervous system that increases heart's activity
sympathetic 
norepinephrine and epinephrine are released in response to which autonomic system
sympathetic 
sympathetic nervous system takes over at a HR of _____ bpm
110 
list the 4 factors affecting SV
1. ventricular stretch 2. ventricular filling 3. contractility 4. afterload (arterial pressure) 
describes the positive relationship b/w ventricular stretch and stroke volume
frank-starling law 
amount of blood that comes back to the heart from the veins
venous return 
contraction force of the myocardium
contractility 
List the 3 factors affecting TPR
1. vessel length 2. blood viscosity 3. vessel diameter (greatest influence) 
what are some diseases that can affect blood viscosity
- sickle cell anemia - blood doping - high bp 
during dynamic aerobic exercise, the is an increase in _____ BP only
systolic 
during static exercise, ______ BP increases
- diastolic - systolic 
used to describe the central and peripheral components and how they relate to VO2max
Fick Equation 
increased blood flow to contracting muscles occur via 2 mechanism
1. increased cardiac output (Q) 2. redistribution of blood flow from inactive organs to working skeletal muscle 
what are the 4 main principles of training
1. overload 2. progression 3. reversibility 4. specificity 
principle of training that says the stimulus must be greater than the norm for improvements to be made
overload 
principle of training: the overload stimulus must occur at a gradual increased of 5-10% per week
progression 
principle of training that states: as soon as a stimulus is removed, the benefits of exercise training become lost
reversibility 
priciple of training: the stimulus applied must be specific to the desired outcome
specificity 
FITT guidelines that improve VO2max
F: 3-5 times per week I: 50-85% VO2max T: 20-60 min T: dynamic; large muscle groups 
T/F: there is a greater increase in VO2max for de-conditioned or diseased subjects
true 
what is the average VO2max increase with training
15% 
______ accounts for 40-65% of VO2max
genetic predisposition 
_____ doesn't change much even with prolonged exercise
Heart Rate 
3 factors that change stroke volume with training
1. **increased end diastolic vol 2. increased contractibility 3. decreased TPR 
what factors increase end diastolic vol in the first 6 weeks of training
1. increased plasma vol *** 2. filling time and venous return increases 3. increased ventricular vol 
what is responsible for the increased a-v difference during training
- increase in capillary density; more blood leaving heart - increase in mitochondrial density 
increase in the size of a cell
hypertrophy 
increase in the cellular number
hyperplasia 
muscle cell
muscle fiber 
motor neuron and all the cells it innervates is known as
motor unit 
most responsible for the initial gain in strength
neural adaptations 
most responsible for strength gains after the first 6 weeks
hypertrophy 
resistance training increases the ability to activate _____ motor units
tyep 2x 
what are the 4 major neural adaptations that occur in the 1st 6 weeks of training
1. motor unit firing is enhanced 2. neuromuscular junctions become wider/ develop more AcH receptors 3. cross-education 4. decreased antagonistic activity 
3 major muscle adaptations that occur after 6 weeks of training
1. hypertrophy 2. increased myofibrils (actin/myosin) 3. increased sarcoplasmic content 
T/F: there is no increase in muscle fiber number when hypertrophy occurs
true 
events within a muscle fiber that lead to hypertrophy are known as
cellular signaling events 
3 hormones responsible for hypertrophy
1. testosterone (lipid based) 2. IGF-1(peptide based) 3. GH (peptide based) 
how an animal regulates core body temp
thermoregulation 
animals that have the ability to maintain a constant core body temperature
hemotherms 
core body temperature is regulated by what organ
hypothalamus 
what is the humans core body temp
37 C or 98 F 
exercise increases metabolic rate and can elevate body temp to ______ F
104 
heat transfer through radiation waves
radiation 
the mechanism humans primarily lose heat through at resting state
radiation 
heat transfer from surface to surface
conduction 
heat loss through moving water or air
convection 
the primary mechanism in which humans lose heat during exercise
evaporation 
heat loss through sweat
evaporation 
at rest, how much water is lost through evaporation
1L 
during exercise, how much water is evaporated
5L ( about 1L per hour) 
when athletes have 2-6% loss in body weight during a bout of exercise
critical water loss deficit 
why is critical water loss deficit bad
hinders performance and increases the risk of a heat illness

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