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Classification of Lipids
1) sterols 2) triglycerides 3) phospholipids
Sterols
-cholesterol -cholesterol function: sex hormones, produces vitamin D
Triglycerides
-95% of fat -major storage form of fat
Triglycerides as fatty acids: Unsaturated
Unsaturated if it has a double bond -only one double bond= monounsaturated -at least two double bonds= polyunsaturated
Triglyceride Structure
glyceride connects fatty acid through an ester linkage
Sterol Structure
Hexagons, looks like shapes, is a sterol because of the HO at beginning of chain
Phospholipid Structure
looks like triglyceride, but has P in the structure for phosphorus
Essential Fatty Acids: Linoleic Acid vs Linolenic Acid
Linoleic: 2 double bonds, polyunsaturated (omega 6) Linolenic: 3 double bonds (omega 3)
Cis vs Trans Fatty Acids
Cis: hydrogens on same side Trans: hydrogens on opposite sides
Question 19
Answer: A
What transports lipids/fat to the blood?
lipoproteins
Types of lipoproteins:
-chylomicron -VLDL (very low density lipoprotein) -LDL (low density lipoprotein) -HDL (high density lipoprotein)
Chylomicrons primarily contain:
triglycerides
VLDL primarily contains:
triglycerides
LDL primarily contains:
cholesterol
HDL primarily contains:
protein
Functions of lipids:
-energy -membrane protection -hormone production -myelin -insulation (body temp)
Reducing LDL: how much do you need to reduce?
20-30%
Reducing LDL: saturated fat
decrease to less than 7% of calories= reduces 8-10% LDL
Reducing LDL: dietary cholesterol
decrease to less than 200 mg/day= 3-5% LDL reduced
LDL Reduction: Weight
lose 10 pounds if overweight= 5-8% LDL reduced
LDL Reduction: soluble fiber
ADD 5-10 grams per day= 3-5% LDL reduced
LDL reduction: Plant sterols
ADD 2 grams per day= 5-15% LDL reduced
Dietary factors in CVD: Saturated fatty acids
restrict saturated fatty acids because: -it increases LDL cholesterol -restrict butter -restrict red meat -restrict salad dressing -restrict tropical oils (coconut oil)
Dietary Factors in CVD: Polyunsaturated fatty acids
restrict saturated fatty acids because: -it increases LDL cholesterol -restrict butter -restrict red meat -restrict salad dressing -restrict tropical oils (coconut oil)
Dietary Factors in CVD: Trans-fatty acids
-worse than saturated fat -restrict croissants and chips
Dietary Factors in CVD: Total Fat
-more total fat= more calories -leads to obesity and high blood pressure -increases cholesterol levels
Dietary Factors in CVD: Dietary Cholesterol
doesn't play that big of a role
Dietary Factors in CVD: B Vitamins
Vitamin B12 and Folate -folate beneficial because it lowers homocystene level in your blood -lowers oxidative stress and decreases damage to blood vessels -get folate through citrus (oranges) and enriched grains (oatmeal)
Dietary Factors in CVD: Fiber
Soluble fiber* -lowers heart disease and stroke -soluble fiber decreases blood cholesterol -oatmeal and oranges
Dietary Factors in CVD: Alcohol
red wine -increases HDL -1 drink per day for females, 2 drinks per day for males
Dietary Factors in CVD: Coffee
-tanins/antioxidants reduce oxidative stress, decaf -green tea is the best -antioxidants through fruits and vegetables
Dietary Factors in CVD: Calcium
can help lower blood pressure -low fat dairy
Dietary Factors in CVD: Stanols/ Sterols
works like fiber by reducing blood cholesterol -benecol and margarine
Monounsaturated Fatty Acids
lowers blood cholesterol -olive oil and canola oil
Antioxidant supplements
don't do shit
Inborn errors of Metabolism
Maple Syrup Defect PKU (ketone urea)
How are all amino acids similar?
all have COOH (carboxylic acid)
Functions of Protein: Structural
-Collagen: protein that lines blood vessels and makes up your skeleton -Keritin: nails and hair -Actin/Myosin: muscles
Functions of Protein: Regulatory
-enzymes -hormones (insulin and glucagon) -receptors -transporters (albumin and hemoglobin)
Functions of Protein: Energy
self explanatory my nigga
Albumin
when you're not getting enough protein, albumin decreases -after 21 days, albumin levels reach below normal -Pre-albumin better to detect than albumin
Method 1: Nitrogen balance formula
Nitrogen balance= intake - outtake + 4g -intake through dietary protein -outtake through urine -4g lost through skin/sweat/hair -getting enough protein= 0 -then convert nitrogen to protein, multiply by 6.25
Method 2: Body weight calculation
body weight/2.2 x .75 -body weight (kg) x .75
Greatest source of essential amino acids in diet:
Animal proteins -whole egg -milk -egg white -beef
Semi-Vegetarian
-includes dairy, eggs, chicken, fish -excludes beef and pork
Lacto-ovo-vegetarian
-includes dairy product and eggs -excludes any animal flesh
Lacto-vegetarian
-includes dairy products -excludes eggs and animal flesh
Ovo-vegetarian
-includes eggs -excludes dairy products and animal flesh
Pros/Cons of Vegetarian Diets
Pros: saturated fat from animals, so lower cholesterol levels Cons: protein malnutrition, anemia (lack of B12 and iron), lack of calcium and vitamin D -vegetarians recommended to take supplements
Protein Malnutrition: Kwashiorkor
infant has huge stomach but plenty of muscles -lacking protein (albumin not doing its job) -but adequate calories
Protein Malnutrition: Marasmus
infant looks like a stick figure, lacks muscle -lacks protein -lacks calories -basically starvation

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