Rowan ECE 09.404 - Lecture 12 Measurement of Blood Flow (22 pages)

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Lecture 12 Measurement of Blood Flow



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Lecture 12 Measurement of Blood Flow

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Pages:
22
School:
Rowan University
Course:
Ece 09.404 - Principles of Biomedical Systems and Devices

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Principles of Biomedical Systems Devices PBS D Fall 2004 Polikar http engineering rowan edu polikar CLASSES ECE404 Lecture 12 Measurement of Blood Flow Measurement of Flow Volume of Blood PBS D Fall 2004 Polikar http engineering rowan edu polikar CLASSES ECE404 A measurement of paramount importance concentration of O2 and other nutrients in cells Very difficult to measure Second class measurement blood flow and changes in blood volume correlate well with concentration Third class measurement blood pressure correlates well with blood flow Fourth class measurement ECG correlates adequately with blood pressure How to make blood flow volume measurements Standard flow meters such as turbine flow meters obviously cannot be used why Indicator dilution method cont rapid injection dye dilution thermodilution Electromagnetic flowmeters Ultrasonic flowmeters Doppler flowmeters Plethysmography Chamber electric impedance photoplethysmography because it requires cutting the blood vessel and can cause formation of blood clots Indicator Dilution with Continuous Injection PBS D Fall 2004 Polikar http engineering rowan edu polikar CLASSES ECE404 Measures flow cardiac output averaged over several heart beats The concentration C of an m0 amount of indicator in a volume V m C 0 V an additional ChangeIf in due to amount m is added continuously addedthen the incremental increase indicator m to volume V in concentration is dm dt m CC 0 dVV dt Fick s technique the amount of a substance O2 taken up by an organ whole body per unit time is equal to the arterial level of O2 minus the venous level of O2 times the blood flow Blood flow liters min cardiac output dV dm dt F C dt dm dt Ca Cv Consumption of O2 mL min Arterial and venous concentration of O2 mL L of blood Fick s technique PBS D Fall 2004 Polikar http engineering rowan edu polikar CLASSES ECE404 O 2 consumption mL min Cardiac Output O 2 a O 2 v 250 mL min 5 L min 190mL L 140mL L How is dm dt O2 consumption measured Where and how would



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